Both sides have had an underwhelming season so far yet three points on Tuesday night could serve as a catalyst for the two teams.
Whilst a victory would enhance United's hopes of securing Champions League football for next season, Burnley currently sit rock-bottom of the table and three points would see them leapfrog Newcastle, Watford, and Norwich into 17th.
Rangnick revealed both Fred and Alex Telles have tested positive for COVID-19 and will be absent from the squad as a result.
David De Gea should be available again after not being named in the matchday squad for the FA Cup tie. The Premier League Player of the Month was rested, with Dean Henderson playing and both Tom Heaton and Lee Grant on the bench.
As for the hosts, Sean Dyche said after the 0-0 draw with Watford at the weekend: "Players are coming back fit and we are going to have to maximise the players as much as we can.
"We are still stretched but we have to keep building to take it into next week. We've had players down through COVID and Johann [Berg Gudmundsson] had his appendix out, so he'll be out for a few weeks."
Burnley: Pope, Roberts, Tarkowski, Mee, Pieters, Lennon, Westwood, Cork, McNeil, Cornet, Weghorst,
Manchester United: De Gea, Dalot, Maguire, Varane, Shaw, McTominay, Pogba, Fernandes, Rashford, Elanga, Ronaldo
One to watch:
Our one to watch for Tuesday's encounter is Anthony Elanga.
The 19-year-old has endured a difficult week after his penalty miss proved costly in the penalty shootout against Middlesbrough as United were knocked out of the FA Cup.
And unfortunately, as can be said the same with other players this year, Elanga was then subject to racist abuse immediately after the match on Monday.
Although serious action needs to be taken against the culprits, the best way for Elanga to respond is by putting in a solid performance against Burnley and quieting the hate.
Before the Middlesbrough game, Elanga had been enjoying a great run of form that saw him score against Brentford and have a huge impact against Aston Villa.
The Swede will be disheartened after his penalty miss, but the talented teen can either bounce back and emulate his January form, or perhaps we might see a struggling Elanga against Burnley.
Head to head:
The two sides have faced each other on a total of 133 occasions, with the hosts winning 45 of those games, United being victorious 65 times, and 23 matches ending in a draw.
Burnley, however, have failed to beat Tuesday's visitors at Turf Moor since August 2009, when Robbie Blake scored the only goal of the game.
Since then, The Red Devils have enjoyed trips to Burnley, winning five matches and drawing once.
Across these six matches, Burnley haven't managed to score a single goal against United, whilst the visitors scored 8 times.
This doesn't bode too well for The Clarets, but they might fancy themselves against this highly inconsistent United side.
How to watch:
The 20:00 BST game will be broadcast live on BT Sport 1 from 19:00 BST.
Fans can also tune in via the BT Sport app.