Gregg Berhalter brings USA back to the World Cup after the Stars and Stripes missed out four years ago with a young, hungry squad eager for success.
With five wins and four draws from 12 matches and a Gold Cup title to their name, the Americans will look to make their mark in the international showpiece.
Qualification path
USA entered in the third round of CONCACAF qualifying needing to finish in the top three to reach Qatar whilst fourth place would have placed them in a inter-confederation playoff over two legs.
After draws with El Salvador and Canada, the Stars and Stripes got going over the next two matchdays with convincing victories over Honduras and Jamaica.
A shock 1-0 defeat to Panama was followed by wins over Costa Rica and a key 2-0 triumph against bitter rivals Mexico before going 3-2-2 over their remaining seven fixtures.
Qualification was secured on the final matchday despite a 2-0 defeat in the reverse fixture against Costa Rica with Berhalter's men finishing third behind Canada and Mexico.
Historical performances
USA have made it past the first knockout stage of the World Cup just twice in 1930, when they only needed three matches to reach the semifinals and 2002, securing an appearance in the quarterfinals.
20 years ago in South Korea/Japan, the Stars and Stripes began the group stages with a scintillating 3-2 victory over Portugal after building a 3-0 lead.
A 1-1 draw with co-host nation South Korea was followed by a 3-1 defeat to Poland. Despite that result, the Americans progressed to the Round of 16 as second-place finishers in Group D.
Goals from Brian McBride and Landon Donovan propelled USA past Mexico by a 2-0 scoreline and sent them to the last eight for the first time since 1930, where they narrowly lost 1-0 to runners-up Germany.
USA are 16-time Gold Champions and won the Nations League last year, capped with a thrilling 3-2 win over Mexico in extra time.
Player to watch
Christian Pulisic is the key player for the Americans. He started his career with German giants Borussia Dortmund, scoring 13 goals in 90 appearances for Die Schwarzgelben from 2016-19.
The 24-year old joined Chelsea in the English Premier League and has taken his goal-scoring prowess to another level, doubling his overall tally with the Blues, netting 20 times in 84 appearances.
In international duty, Pulisic has 21 goals in 52 appearances for the Stars and Stripes, including five in qualifying, placing him second on the CONCACAF goal-scoring charts.
Expected lineup
Berhalter's best XI is expected to be:
Turner; Robinson, Zimmerman, Richards, Dest; Adams, Musah, McKennie; Pulisic, Ferreira, Weah
Biggest talking point
The key to success for Berhalter's side will be if he can produce the line-up he has had in mind for a while.
Pulisic and FC Dallas striker Jesus Ferreira provide a potent attacking duo with the likes of Josh Sargent, Paul Arriola, Jordan Morris and Ricardo Pepi also at his disposal.
Chris Richards is a question mark at center-back as he has been suffering through injuries and may see reduced playing time at Crystal Palace. Aaron Long will be ready to take his place if necessary to start alongside the rock-solid Walker Zimmerman.
Matt Turner is the projected starter in goal although Berhalter may opt for Sean Johnson or Ethan Horvath, especially with the Arsenal man held out of the Gunners' most recent Europa League tie.
VAVEL predicts
The Stars and Stripes face Wales in their Group B opener in what ould be a key match in determining who reaches the knockout stages. The much-anticipated fixture with England follows with Iran the final group-stage game.
A win over the Welsh, who needed to qualify for the World Cup through the UEFA playoffs, would do wonders for USA's chances to reach the last 16, with the crowd figuring to be on their side after Wales eliminated Ukraine in the play-off final.
England will figure to be the group favorites and look to make amends for their 1-1 draw with the Americans after a howler let in by Robert Green in their 2006 match cost the Three Lions first place in the group.
America hasn't faced Iran since a shock 2-1 defeat in the 1998 edition. Carlos Queiroz's side look to be the weakest side of the four teams in Group B and facing them last could be important should Berhalter's men need a result.
While topping the group looks to be a challenge, second place is certainly feasible, especially if USA can top Wales as previously mentioned. With this side so young, Berhalter will look to make sure the future is now.