The 6-2 demolition in North London seemed to have been the wake up call Leicester needed, sparking their season into life with Brendan Rogers' side taking 10 points from their last 15 and recording three clean sheets on the bounce.
Former Leicester man, Riyad Mahrez saw his tame penalty effort denied by Gregor Kobel at the Signal Iduna on Tuesday night further adding to the Algerians' spot kick woes after also failing to convert against Copenhagen.
With that being his fourth penalty miss in 2022, many will expect Mahrez to be relieved of his penalty taking duties.
With one victory in their last four, City will look to put an end to their minor blip and pile pressure onto league leaders Arsenal before they face Nottingham Forest on Sunday.
The last time the two sides met was a nine goal thriller as Man City ran out 6-3 winners on Boxing Day.
In his press conference ahead of the tie, Rodgers said: "In terms of the squad, we'll monitor Jonny over the next few games.
"Wilfred Ndidi has been back training with the squad. The most important thing is he's back training with the squad and he's looked fine with the players"
Long term absentees, Ryan Bertrand (knee) and Ricardo Periera (achilles) remain on the sidelines
The fitness of Erling Haaland will be assessed in Friday's training session before the decision is made if he will feature.
The forward was withdrawn at half-time against Dortmund, his former club, with a slight ankle issue and a fever.
"He (Haaland) feels better but we train this afternoon and we will assess him in the next few hours" Guardiola said in his press conference.
He added: "We will see how he feels. After we will decide- I will know in two hours if he can play."
"They are not ready for Leicester", Pep confirmed.
Leicester: Ward; Castagne, Amartey, Faes, Justin; Soumare; Maddison, Tielemans, Dewsbury-Hall, Barnes, Daka
Man City: Ederson; Akanji, Dias, Laporte, Cancelo; Rodri, Silva, De Bruyne, Grealish, Foden, Alvarez
With four goals and an assist in his last five games, Maddison is hitting form at just the right time with the World Cup on the horizon.
It is clear that Leicester's revitalisation coincides with the Englishman performing at his best again.
He leads the way for the highest scoring midfielder in the division with six strikes.
In addition, only six players are responsible for a higher percentage of their team's goals this campaign with the 25-year-old having a direct hand in 29% of the Foxes' goals this season.
If Leicester are to snatch any points from Guardiola's side then Maddison will have to be at his brilliant best.
Foden has had his best ever start to the season numbers wise, notching six goals and four assists as well as creating an impressive 18 chances.
The 22-year-old looks a certainty to be on the plane to Qatar.
With City's prolific Norwegian a doubt for this fixture, Foden may have to take on the extra burden in attack and step up in his teammate's absence- a task he is more than capable of fulfilling.
Where is the game being played?
What time is kick-off?
The match is scheduled to kick off at 12.30pm on Saturday.
Where can I watch?
Fans in the UK can watch the match live on BT Sport 1.