It's the last game before yet another international break, so both teams will want to go into the two week hiatus off the back of a good result - whatever that might look like for the respective managers.
For Thomas Tuchel, it's hard to see how anything but a win in this game can be taken as a good result, given the positions of the two teams in the league at the moment.
Having only lost one game in domestic competitions this season, conceding just three goals along the way, the Blues are in a fantastic position, setting the pace at the top of the table.
Meanwhile, from the perspective of Sean Dyche, it appears relatively likely that the Clarets would view getting any points at all from this game as a huge positive in their bid to ensure they aren't left behind at the bottom.
They may only have had one win thus far, but it did come in their previous game - a 3-1 triumph over Brentford - so the visitors will hope they can build on what was an impressive performance last time out at Turf Moor.
During his pre-match press conference, Thomas Tuchel said: 'No news for the match tomorrow for Romelu [Lukaku] and Timo [Werner], both of them are out. Christian Pulisic is back in with the group, unfortunately Marcos Alonso and Mateo [Kovacic] are out.'
There's also set to be no Marcos Alonso or Mateo Kovacic, the former of which injured himself at the end of the win against Malmo in midweek, and Mason Mount appears to be a potential doubt, though he is in the squad.
Sean Dyche also sat down with the media and he told them: 'Dale [Stephens] is on the grass and has joined in with the group. He is getting stronger all the time, the next stage is to get him into game time. Aaron Lennon has had a bit of illness so we will wait and see on him.'
It's similarly positive news for Burnley fans as they have an almost entirely-fit first team squad, save for a potential Aaron Lennon absence and Dale Stephens, who has been out for some time.
Dyche will need every player to be at their best if they are to come away with anything, but having next to no injuries is always a good place to start.
Mendy; Christensen, Silva, Rudiger; James, Jorginho, Kante, Chilwell; Hudson-Odoi, Havertz, Pulisic
Pope; Lowton, Tarkowski, Collins, Taylor; Gudmundsson, Cork, Westwood, McNeil; Cornet, Wood
For Chelsea fans, things must feel as though they couldn't really be going much better, regardless of the competition they are involved in, whether it's domestic or European.
Chelsea FC (@ChelseaFC) November 4, 2021
On the other hand, it's been a fairly difficult opening few months for the Clarets, who have struggled to get many results at all, sitting in 18th place in the league going into this one.
Burnley FC (@BurnleyOfficial) October 30, 2021
They can take some heart from the fact they picked up their first three points of the campaign last weekend, but it will be a performance for the ages if they are to do the same in this game.
Ones To Watch
When choosing one player to keep an eye on in this game, it makes sense to go with someone who is involved in all aspects of the game - both attacking and defending, with Tuchel's team top in both of those departments.
Therefore, with the performances Ben Chilwell has been putting in recently, it's only fair that the left back is the one to watch for this game, for all aspects of his play.
In a team which is often regarded as one of the least-attacking in the league, one player who has set out to change that reputation this season is that of Maxwel Cornet.
On top of that, three of his four goals that he has scored in total for the club have come away from home, which he will hope is a good omen for his travels this weekend.
Previous Five Meetings
When it comes to matchups in the past, the results don't make for particularly pretty reading for Burnley supporters, especially in the context of the most recent five games.
The first of those came back in April 2019, when the two sides played out an entertaining 2-2 draw at Stamford Bridge, with all four goals coming in the first 45 minutes of the game.
It was a back and forth battle, with Jeff Hendrick putting the away side ahead at first, before the Blues came back to be 2-1 up, but an Ashley Barnes goal meant Dyche's team left West London with a well-earned point.
Strangely enough, that was the last time these two teams played one another with fans present in the stadium, despite it being almost 22 months ago since the fixture was played.
That's because the 3-0 away win that Chelsea secured in October 2020 came when Covid restrictions were, if anything, being strengthened, in a similar fashion to that of the Blues' performances at that time.
It was a fairly routine victory in Lancashire, which saw the first league start for Hakim Ziyech and he took his chance with aplomb, scoring one goal and helping to set up another one.
It was a third manager in just five games during the most recent clash between these two, and it saw Thomas Tuchel manage his second game in charge of the Blues.
How To Watch
For viewers in the UK, this game won't be broadcast live on TV, but highlights will be available soon after the match ends on the Sky Sports YouTube channel.
Otherwise, you can follow the game right here on VAVEL with our live blog that will give regular score updates and analysis right throughout the match.