The two sides met very recently indeed, with the Blues running out 3-0 winners in the league fixture played just 11 days before this next encounter.
Even that was via a penalty, and with the attacking output also looking strong - they've scored 13 goals in just six games - it will be a tough test for Villa.
Speaking of Dean Smith's side, they've had a slightly more mixed opening to the campaign, currently sitting in 10th place with two wins, two losses and a draw to their name.
They showed their promise in their last outing with an impressive 3-0 win against Everton, but their inconsistency shines through in the fact the result prior to that was the same scoreline against them - against Chelsea no less.
In his pre-match press conference Tuchel said: '[Edouard] Mendy cannot play and he is not training so far. We will do what we can for Saturday [against Manchester City]. We hope he trains on Thursday so he can be back for Saturday.’
Dean Smith spoke to the media after his side's win against Everton at the weekend, and suggested to the press that there were a few problems within his squad.
In comparison to their opponents, Villa's injury list makes for considerably tougher viewing, with three key players in the form of Matty Cash, Matt Targett and Leon Bailey all set to be on the sidelines.
Kepa; Chalobah, Azpilicueta, Rudiger; James, Saul, Loftus-Cheek, Chilwell; Hudson-Odoi, Werner, Barkley
Aston Villa (5-3-2):
Steer; Guilbert, Konsa, Tuanzebe, Hause, Young; Nakamba, Sanson, Buendia; Watkins, Archer
Just over a month into the competitive season and the Blues could scarcely have envisioned a more idyllic start to this campaign with their results thus far.
Chelsea FC (@ChelseaFC) September 20, 2021
Not only has the defence been as rock solid, if not more so, than last year, the attack's potency has also improved with the addition of Romelu Lukaku - even if there were three more unlikely scorers in their previous game against Tottenham Hotspur.
The visitors to Stamford Bridge haven't had quite as exciting a start but it hasn't been bad by any means either, especially looking at their most recent result.
Aston Villa (@AVFCOfficial) September 20, 2021
A 3-0 demolition of Everton showed the best of all parts of their play - although considering two of their three goals came through players who are injured for this game (Cash and Bailey), trying to replicate such a performance will be a very tough task.
Ones to Watch
With what is likely to be a heavily rotated starting eleven for the home side, it 's hard to pick out one standout player to keep an eye on, but Trevoh Chalobah could be a good candidate.
The 24-year-old was an unused substitute against Everton and will clearly benefit from getting some minutes in after his longer-than-anticipated hiatus.
Quite how he managed against what is still likely to be an experience Chelsea defence is yet to be seen, but he could be the one to cause problems in the Blues' backline.
Previous Five Meetings
The Blues will hope to continue their fine form against the Villans, avoiding any slip-ups like one that occurred just a few months ago in the league.
In fairness, that was Dean Smith's team's first season back in the top flight, and they were by no means overrun by then-Chelsea boss Frank Lampard's side.
The next meeting between the two came in a much-changed footballing environment, as the Premier League had just returned from a lockdown-enforced break.
A tight 1-1 draw in London followed, in which another Giroud goal was cancelled out by an Anwar El Ghazi strike, giving Villa a well-earned point with match still behind closed doors.
In fact, that game was relatively near the end of Lampard's tenure in charge and could even be pointed to as one of the defining reasons why the former coach lost his job.
There were more dropped points for Chelsea a few months later in the very final league game of the season when fans finally returned to football stadiums.
Their presence undoubtedly contributed to an eventual 2-1 win for Villa, during a dramatic top four race that went right down to the wire, with Tuchel's side successful in the end.
Finally, in the most recent encounter between the two sides, there was a scoreline which, while not necessarily reflective of the game itself, did show the gulf in class between the two sides.
Lukaku ran riot just over a week ago, scoring two in a 3-0 win, and Villa defenders may still be having nightmares over facing the Belgian - though they'll be grateful to hear that he likely wont't feature due to the expected squad rotation.
How To Watch
This Third Round Carabao Cup game won't be being broadcast live in the UK, but regular score updates from all the round's games can be followed on Sky Sports News' 'Gillette Soccer Special' programme.
Otherwise, you can also follow the game right here on VAVEL, where we'll bring you updates from around two hours before kick, right throughout the game.