The Reds are desperate to arrest their poor run of form; they have won just three of their nine matches in all competitions.
With those two facing each other in quick succession, Jurgen Klopp's side could forge ahead in the group with two victories against their Scottish opposition.
Meanwhile, the visitors are second in the league behind arch-rivals Celtic and bottom of Group A with no points after heavy losses to Ajax and Napoli.
They head to Merseyside with confidence however after beating Hearts of 4-0 at the weekend.
Giovanni Van Bronckhorst has challenged his side to believe that they can cause a famous upset and compound the Reds misery.
Left-back Andy Robertson, who is a boyhood Celtic supporter will miss the clash due to a knee injury.
Fellow Scot Calvin Ramsay trained but the game is expected to come too soon for the summer signing.
Ibrahima Konate is also back in training however he is not expected to feature as he recovers from a knee injury.
The Gers are without James Sands, who was sent off last time out against Napoli.
Therefore Conor Goldson and former Liverpool forgotten man Ben Davies should be the partnership in central defence.
Tom Lawrence, Jon McLaughlin and Kemar Roofe are doubts after missing the weekend's dominant win over Hearts.
John Souttar, Filip Helander, Nnamadi Ofoborth and Ianis Hagi and are all expected to be out until after the World Cup.
Alisson; Alexander-Arnold, Matip, Van Dijk, Tsimikas; Henderson, Thiago,Elliott; Diaz, Jota, Salah
McGregor; Tavernier, Goldson, Davies, Barisic; Lundstram, Davis, Jack; Tillman, Colak, Kent
Liverpool- Luis Diaz
One of the only Liverpool players to come out of the game in Naples with any credit, Luis Diaz curled in a superb consolation from outside the box.
He has four goals and an assist in 10 games so far this season continuing on from his electric introduction to English football.
One of the only bright sparks in a torrid season so far for the Reds.
Rangers- James Tavernier
Right-back James Tavernier is the heartbeat of this Rangers side and he contributed to an incredible 35 goals last season.
He was even the top scorer in the Europa League with seven, however his form has been patchy this season.
He has managed three goals and four assists in 14 games so far this season but his performances in defeats to Celtic, Napoli and Ajax have been concerning.
When he struggles, Rangers struggle. So he needs to have a big performance at Anfield.
Where is the game being played?
The clash is at Anfield in Liverpool.
What time is kick-off?
Kick-off is at 20:00 BST on Tuesday 4th October.
How can I watch?
The match is live on BT Sport 2, with coverage beginning at 18:30 BST.