The South West London club have three tough opening games that will have fans across the world on their feet. But, that is just the start.
Here are all of Chelsea's the key clashes for your calendar.
Opening Day: 14th August 2021 vs Crystal Palace (H)
Tuchel will lead the Blues out on home turf for the first time since the club’s fairytale Champions League final triumph in Porto, as Chelsea look to win successive opening day bouts for the first time since 2014.
Meanwhile, the Eagles will look to extend their opening day unbeaten streak to four years.
The Blues have won eight of the last ten meetings with Palace losing just twice, in which 31 goals were scored between the two sides. Goal-fest.
Champions League Final Replay: 25th September 2021 vs Manchester City (H)
After blood, sweat and tears in Porto, the 2021 Champions League finalists will reconvene in a pivotal fixture that could decide who finishes the season victorious.
Pep Guardiola will be out for vengeance, meanwhile Tuchel’s side will look to build upon the club’s three game win streak over the Cityzens.
Relighting the FA Cup Final drama: 20th November 2021 vs Leicester City (A)
Acrimony will flood through the veins of Leicester City and Chelsea fans ahead of this clash.
After a sour ending to what Ben Chiwell thought was a miraculous FA Cup Final equaliser, this game will be fuelled by spite and zeal.
Boxing Day Special: 26th December 2021 vs Aston Villa (A)
Boxing Day is one of the most prestigious days in the footballing calendar.
New Year's Day: 1st January 2022 vs Liverpool (H)
Chelsea have played on New Year’s Day just three times in the last ten years; the Blues won, drew and lost one a piece.
Chelsea have won three of the last five meetings with Liverpool at Stamford Bridge in the Premier League, losing just once and drawing the other.
Battle of the Bridge: 22nd January 2022 vs Tottenham Hotspur (H)
Chelsea versus Tottenham has become a staple in the Premier League fixture list.
The battle of the bridge. This is proper football. pic.twitter.com/YiwHDRvAkG— Raf 🇵🇹 (@CFC_Raf) February 4, 2021
The Battle of the Bridge will undoubtedly see a blanket of red mist descend over Stamford Bridge once again.
Blue vs Red: 12th February 2022 vs Arsenal (H)
The Blues have lost all of their last three meetings with the Gunners heading into the 2021/22 season.
Final game of the season: 22nd May 2022 vs Watford (H)
Having lost the final game of the 2020/21 season away to Villa, Tuchel will take confidence from finishing the season at home.
It has been nearly 20 years since Chelsea have lost the last game of the Premier League season when playing at home. Villa defeated the Blues 3-1 in 2002.