Philadelphia moved up to third place in the Eastern Conference following a 1-0 victory over Nashville while Toronto drew 1-1 with Montreal, but the Reds still sit rock-bottom of MLS with just 20 points.
Toronto has a long list of players currently out. Omar Gonzalez and Ifunanyachi Achara were injured last week, Ralph Priso and Ayo Akinola are out for the season while Tsubasa Endoh and Yeferson Soteldo remain sidelined.
The one player who has a chance of featuring is Dom Dwyer, but he is listed as doubtful.
Philadelphia will be without goalkeeper Andre Blake, who is back in Jamaica following the passing of his grandmother. Cory Burke will miss out through injury while Sergio Santos returned against Nashville and will be available as a substitute.
Toronto FC: Bono; Laryea, Lawrence, Mavinga, Auro; Delgado, Bradley; Osorio, Pozuelo, Shaffelburg; Mullins
Philadelphia Union: Blake; Wagner, Elliott, Glesnes, Mbaizo; Fontana, Martinez, Bedoya, Monteiro; Gazdag; Przybylko
Jozy Altidore (Toronto FC)
In an otherwise dismal year for the Reds, he salvaged a bit of pride with a stunning free-kick that earned a point against Canadian rivals FC Montreal and remains one of Toronto's biggest attacking threats.
Kacper Przybylko (Philadelphia Union)
He put away a penalty for the only goal of the match against Nashville and while head coach Jim Curtin has said his side have to "manufacture" goals, the Pole has 11 goals and is Philadelphia's most dangerous offensive weapon.
The only meeting between Toronto and Philadelphia this year ended up as a 3-0 victory for the Union with Jakob Glesnes, Gazdag and Santos scoring within the first 36 minutes.
The match will be streamed nationally on ESPN +. TSN1 will have all of the action in Toronto while PHL17 and the Union's official will carry the action in Philadelphia. Kick-off is set for 7:30pm.