The Titans have only won three games in this season so far and find themselves slipping out of contention for a spot in the finals, currently sitting in fourteenth place in the NRL ladder.
Dale Copley will return from an injury, pushing Phillip Sami to wing and Treymain Spry out of the team. Kevin Proctor is also back from a bicep injury and will come into the back row in place of Beau Fermor.
Jai Whitbread sees himself promoted to the bench with Sam Lisone and Treymain Spry dropping out of the extended squad. Jamal Fogarty has also been named in the squad despite going off injured last week.
Viliame Kikau has pulled out of the side due to a calf injury, with Billy Burns starting in the second row. Pat Hollis has also been omitted from the reduced squad.
Caleb Aekins returns as fullback in place of Dylan Edwards while Brent Naden moves to centre for Dean Whare with Malakai Watene-Zelezniak called up on the wing. Api Koroisau is also injured and replaced by Mitch Kenny at hooker.
Starting 13: Thompson, Don, Kelly, Copley, Sami, Taylor, Fogarty, Fotuaika, Clark, Joliffe, Proctor, Hipgrave, Arrow
Interchange: Boyd, Peachey, Wallace, Whitbread
Reserves: Stone, Peats
Starting 13: Aekins, Mansour, Naden, Crichton, Watene-Zelezniak, Luai, Cleary, Tamou, Kenny, Fisher-Harris, Martin, Burns, Yeo
Interchange: May, Leniu, Leota, Burton
Reserves: Laurie, Smith
Ones to watch
Gold Coast Titans - Anthony Don
'The Don' could be one of the Titans' main threats going forwards, an advantage for the hosts in the air.
Anthony Don is a good option when it comes to cross field kicks for the titans. The key for the side will be for them to aim it far enough out wide to not attract Stephen Crichton or Brent Naden, who are both extremely capable of shutting down aerial raids.
Penrith Panthers - Stephen Crichton
Crichton has already impressed in his first full season of first-grade football, and he could stand out on Sunday.
The Gold Coast have poor defence on their edges and Penrith's left-side has already proven to be a handful for even the best sides in the NRL this year.
If the Titans give Crichton enough space or time he will be able to take advantage of the hosts.