New York is unbeaten in their last four matches and are coming off of a 1-1 draw against Philadelphia while Cincinnati has lost four in a row.
The Orange and Blue sacked manager Jaap Stam and replaced him with Tyrone Marshall on an interim basis. Chris Albright was hired as the club's new general manager.
FC Cincinnati will be without Gustavo Vallecilla, who is suspended after picking up his fifth yellow card of the season. Maikel van der Werff will also be sidelined as he continues to battle a hernia injury. Joseph-Claude Gyau is a doubt with an Achilles injury.
Fabio is out with a calf injury for the Red Bulls. New York will also be without Kyle Duncan, suspended due to yellow card accumulation and Lucas Monzon, battling a hamstring issue.
FC Cincinnati: Tyton; Castillo, Cameron, Bailey, Mataritta; Barreal, Kubo, Medunjanin, Atanga; Acosta; Brenner
New York Red Bulls: Coronel; Gutman, Nealis, Edwards; Duncan, Yearwood, Davis, Tolkin; Carmona, Kilmala, Casseres Jr.
Ones to watch
With Cincinnati in last place in the Eastern Conference, there haven't been too many bright spots for the Orange and Blue this season, but attacking midfielder Carlos Acosta has scored in consecutive games for the first time in 2019 as he made his 150th appearance for the club against Toronto.
Omir Fernandez has been the standout player in attack for New York during their recent good run of form, scoring three times, including the match-winner in the Hudson River Derby last Saturday against NYCFC and the equalizer against Philadelphia.
This is the seventh all-time meeting between FC Cincinnati and New York with the Red Bulls having won three, the Orange and Blue two with one draw.
The match will be streamed nationally on ESPN+. Television coverage will be provided by the MSG Network in New York and WSTR Star 64 in Cincinnati.
A local stream is available on fccincinnati.com. Kickoff is set for 7:30pm.