Tariq Lamptey is still two to three weeks away from being ready for action while striker Danny Welbeck is progressing in recovery from his knee issue and is a week away from returning to training according to manager Graham Potter.
Harry Kane has been ruled out with damage in both ankles while Giovani Lo Celso, Dele Alli and Sergio Reguilon will join Kane on the sidelines. Reguilon sustained an injury in training on Tuesday and could miss three to four weeks.
Brighton & Hove Albion: Sanchez; White, Dunk, Webster; Veltman, Gross, Bissouma, March; Mac Allister, Trossard; Maupay
Tottenham Hotspur: Lloris; Davies, Dier, Rodon, Aurier; Winks, Hojbjerg; Son, Ndombele, Bergwijn; Vinicius
Spurs eked out a 2-1 win on November 1st at the Tottenham Hotspur Stadium. Kane's 13th minute penalty gave the hosts the lead after VAR had determined Adam Lallana had fouled him.
Lamptey equalized in the 56th minute, sweeping past after Solly March had appeared to have fouled Pierre-Emile Hojbjerg in the build-up.
Gareth Bale came on as a substitute and powered home Reguilon's cross past Brighton goalkeeper Robert Sanchez in the 73rd minute for his first Spurs goal since 2013.
Neal Maupay is the main source of offense for Brighton, netting seven times in the Premier League this season while no other Seagulls player has more than two.
Heung-min Son has been Spurs' biggest threat, netting 16 goals in 31 appearances across all competitions, including a four-goal performance against Southampton in September.
Potter is aware of the loss of Kane, but feels Spurs will adapt, especially with Jose Mourinho at the helm.
"It would be unfair of me to say they have another Harry Kane in the group as he is a fantastic player", he said. "It's going to be hard to replace him, but the squad Tottenham have I am sure they will find a solution.
"I watched Jose work whilst he was at Real Madrid. He's always been someone I looked up to and had an interest in since he stepped into the UK. He is a master."
Mourinho knows Brighton's league position isn't indicative of the quality they possess and is not overlooking the Seagulls.
"Every game is tricky", he said. "The first can lose at home to the bottom, like it happened on Wednesday night. When we went to Sheffield United, I said exactly that, don't look at them as bottom of the table.
"Any team can beat any team, but to win football matches, we cannot make mistakes like we did against Liverpool."
The match will be shown on Sky Sports Premier League and Sky Sports Main Event from 7:15pm.