Southampton will not have an easy task at hand, as West Ham have started the season on a hot streak of form. The same can't be said about the Saints however, as they are yet to win a game.
West Ham 3-1 Southampton, 29 February 2020
The final home game at the London Stadium with full attendance before the lockdown produced a cagey and action-packed match up.
West Ham were desperate for three points after a nine-game winless streak, Southampton on the other hand were on the up from their morale killing 0-9 loss to Leicester City, they went into this game with four wins from their last seven.
West Ham punished James Ward-Prowse for a poor clearance 15 minutes in, Pablo Fornals wonderfully slotted Jarrod Bowen in who made it 1-0 with a delightful finish. This was Bowen's first goal for West Ham, it came on his full home debut.
It didn't take long for West Ham to gain their lead back, nine minutes later Sebastien Haller used his physical advantages and beat Alex McCarthy to the ball, heading it down and sliding it in to make it 2-1 to the hammers.
In the 54th minute, Pablo Fornals grabbed his second assist of the match with a composed ball over the Southampton defenders head. Michail Antonio used his pace and power to blast it past McCarthy and made it 3-1 to West Ham.
West Ham 3-3 Southampton, 7 May 1994
Own goal dramas, fine lines between relegation and safety and a goal fest, this game has everything to make it a classic.
Southampton were in need of a victory at The Boleyn to guarantee a Premier League status going into the 1994-1995 season.
Danny Williamson made a dream start in the 11th minute, it was his home debut for West Ham. Both defenders forgot their job in a moment where Williamson snuck behind and calmly finished.
On the stroke of half time, Matt Le Tissier scored an excellent free kick to steal a goal before half time. It was an unstoppable effort that flew past Ludek Miklosko into the top right corner.
After the interval, Neil Maddison got on the end of a Le Tissier cross to give the saints the lead for the first time. An excellent piece of hold up play from Le Tissier, followed by an even better cross. Southampton needed to hold on if they wanted any guarantee of Premier League football in the following season.
Just 10 minutes later, an excellent run from West Ham top scorer, Trevor Morley, was denied a finish by David Beasant. Martin Allen followed up on the rebound to make it 2-2.
Southampton made an instant reply when Iain Dowie was brought down in the box, referee Gerald Ashby quickly pointed to the spot. Le Tissier slotted his second of the game home and regained the lead.
It seemed that three points were wrapped up and Southampton would be heading back to the south coast with a win and comfortable in the knowledge that they would be playing top flight football once again. This was all until a devastating own goal from Kenneth Monkou evened it up again.
For the Saints, luck was on their side and a point was enough to maintain Premier League status.
Southampton 3-2 West Ham, 19 August 2017
Manolo Gabbiadini scored Southampton's first home goal in six matches after just 11 minutes.
Things then got worse for West Ham when Marko Arnautovic saw red for an elbow against Jack Stephens, this was only his second game for the club. A disasterful five minutes from West Ham also found Saints double their lead. Dusan Tadic netted from 12 yards after former Southampton player, Jose Fonte, brought down Steven Davis.
Despite the situation, West Ham didn't give up showing any effort and in the 44th minute found themselves back in it. Antonio spun and quickly struck at goal, Chicharito scored his first goal for the club with a rebounded effort.
West Ham then found a leveller on 73 minutes, Chicharito scored his brace to spark what seemed an unlikely comeback.
A second penalty was awarded for Southampton with seconds left on the clock, Charlie Austin stepped up and buried it to ensure the first win for Mauricio Pellegrini as Saints boss.
There have been some cracking match ups between these two teams over the years. Either side can play brilliant football on their day, another highly energetic and action packed game could well be in store this Saturday 11 September.