It took longer than the Belgian would have liked to get into the match, but a scintillating performance from then on earned DreamMaker the all-important top spot.
The Special One hit 78% of his doubles in a well-contested battle against The Machine, reminding viewers of how competitive this year's Premier League is proving to be.
De Sousa Once Again Shines
De Sousa was devastating on the outer ring against Wade and broke in the fifth leg to open up a 3-2 advantage, which quickly escalated into a 6-3 lead.
The Portuguese star had to withstand a late fightback from the Englishman before breaking with an 11-dart leg to record his second win of this year's competition.
Voltage averaged 110 in the opening four legs, but Anderson's break in the fifth proved to be a pivotal.
The Flying Scotsman then raced into a 5-2 lead but found himself in with a narrow leg advantage going into the 12th. Cross missed a dart at double 18 and then at double nine, before Anderson capitalised and took home the two points.
Dimitri Van den Bergh tops the table
Van den Bergh started his eagerly-anticipated clash against Clayton averaging 10 points fewer, but he eventually found his rhythm and devastatingly condemned the Welshman to his second defeat in this year's tournament.
After five consecutive broken legs, Van den Bergh crucially edged into a 5-3 lead with a 104 finish, before breaking a further leg and holding his own to earn his place at the Premier League summit.
Clayton's doubles proved to be the catalyst to his downfall with both players ending the contest averaging well over a ton.
In a match where both struggled with doubles, van Gerwen just about done enough to secure the two points with Glen Durrant showing some signs of improvement.
The current Premier League champion won the first leg and missed an opportunity to claim a second straight after.
It was not a trademark Van Gerwen performance, but he ultimately secured maximum points and will be looking to eradicate his display from memory before tomorrow night's clash with Gary Anderson.
Nathan Aspinall averaged 105.2 in a convincing win against Peter Wright and demonstrated once again why he is a genuine contender for this year's competition.
At 3-3, The Asp won four legs on the bounce to jump up to eight points and seemingly eliminated the possibility of being caught come judgement night.
Unibet Premier League
Night Six - Monday April 19
Marshall Arena, Milton Keynes
Rob Cross 5-7 Gary Anderson
Jose de Sousa 7-5 James Wade
Jonny Clayton 3-7 Dimitri Van den Bergh
Glen Durrant 3-7 Michael van Gerwen
Nathan Aspinall 7-3 Peter Wright
Night Seven - Tuesday April 20
Glen Durrant v Jose de Sousa
Rob Cross v Dimitri Van den Bergh
Nathan Aspinall v Jonny Clayton
Peter Wright v James Wade
Michael van Gerwen v Gary Anderson