After a 1-1 draw in the first leg, Wolverhampton Wanderers and Olympiacos are both looking for a victory to take them into the quarter finals of the Europa League.
The only advantage for Wolves ahead of this game is their away goal which has a history of proving importance in these European ties.
After a strong season for Wolves, they unfortunately fell short at the last minute, finishing seventh place in the Premier League and with Arsenal's FA Cup victory last weekend, Wolves now need to win this competition to gain another shot at European football again next season.
The first leg
Despite the red card for Olympiacos centre-back, Ruben Semedo, half way through the first half, the game was an even affair with the red and whites holding most of the possession.
Youssef El-Arabi put his side ahead in the 54th minute before Wolves got their equaliser from a well-worked free-kick, put in by Pedro Neto.
The goal-scorer told Wolves TV that he was 'pleased with the goal but not with the result' in Athens, and the Wolves side will be looking to better their performance for Thursday night and get the win they need to progress in the competition.
Wolves started well after the restart, winning their first three matches but they failed to keep up the momentum, seeing them win just two of their last six games, facing losses to London sides Chelsea and Arsenal and fellow top six challengers Sheffield United.
Olympiacos, on the other hand, have had a great spell of form post-lockdown, with just one loss and one draw in the twelve matches played. They will have the momentum needed going into this game so Wolves need to make sure their confidence hasn't been knocked by their unfortunate end to the 2019/20 season.
Wolves have the their full first-team squad to choose from, with no injury concerns, so they could take full advantage of the new five substitution rule that was used in the Premier League as they'll have the options on the bench.
Olympiacos are without Semedo after the sending off in the first leg and their first keeper Jose Sa is unlikely to be in the team sheet after suffering a wrist injury. Wolves will look to exploit this weakness in defence.
Wolves predicted lineup: Patricio, Boly, Coady, Saiss, Doherty, Dendoncker, Moutinho, Neves, Neto, Jota, Jimenez.
Olympiacos predicted lineup: Allain, Elabdellaoui, Ba, Cisse, Tsimikas, Guilherme, Bouchalakis, Camara, Valbuena, El-Arabi, Masouras.
Where to watch
The match will be televised at 8:00pm on BT Sport.