The side managed by the newly appointed Bruno Lage failed to get off to the greatest of starts on the opening weekend as they suffered a 1-0 defeat away to Leicester City, but will be looking to bounce back in front of a packed out Molineux for the first time since March 2020.
However last night, Nuno's outfit lost the first leg of their Europa Conference League play-off tie at Pacos Ferreira despite playing a much rotated and young side out in Portugal.
The North London side will surely be going to Wolves with confidence though considering that they have only lost one of their seven Premier League encounters at Molineux with their last taste of defeat coming back in 2010 as a David Jones strike was enough to seal a 1-0 victory for the hosts.
In the Wanderers first home game of the new campaign, Lage still has a number of players unavailable to him in the form of Jonny Otto (ACL), Willy Boly (hamstring), Daniel Podence (groin) and Pedro Neto (fractured kneecap) who is not expected to return to action until at least February.
New signing Yerson Mosquera is still a doubt with a hamstring problem, despite him returning to training this week.
Last time out at the King Power Stadium, Lage opted to go with a 3-4-3 system with Romain Saiss, Conor Coady and Max Kilman making up the back three.
Considering the opposition that he is coming up against, it is likely that the Portuguese will go with the same shape and with the current absences that Wolves have at centre back, it is unlikely that their backline will change.
However, Nelson Semedo could feature again for the Wanderers in the place of Ki Jana Hoever after featuring for the under 23's in midweek to gain fitness.
Rayan Ait-Nouri who was brought in on a permanent basis in the summer could come back in at left wing-back instead of the experienced Marcal while Ruben Neves and Joao Moutinho are likely to retain their spots in the centre of midfield.
In terms of the front three, Wolves have limited options available with Neto and Podence still out meaning that Raul Jimenez, Adama Traore and loan addition Francisco Trincao are likely to remain in the starting 11 on Sunday.
Sa, Kilman, Coady, Saiss, Ait Nouri, Semedo, Neves, Moutinho, Trincao, Traore, Jimenez
Ahead of Spurs trip to Molineux, Santo has no fresh injury concerns or doubts with the only question being whether Kane will play any part on Sunday surrounding the rumours that Manchester City are preparing a £150 million bid for the England captain.
Although the 28-year-old has returned to training with the squad bringing positive news to Spurs fans meaning that there could be a chance that he plays some involvement in the clash at the weekend.
In Nuno's first game in charge of the club, he played a 4-3-3 formation and it is likely that on his return to Wolves that he will make no changes to his back four considering how they limited City to little in terms of clear cut chances last weekend.
After impressing out on loan last season at Norwich City, Oliver Skipp was given the go-ahead to start against last campaign Champions League finalists and is likely to do so again this time round even though Harry Winks could slot in to replace the 20-year-old.
The game at Wolves could mark Bryan Gil's and Christian Romero's first league appearances for their new club after joining in the summer from Sevilla and Atalanta on loan retrospectively.
However, after playing the full 90 minutes yesterday both players are unlikely to start meaning that Santo is likely to stick with the same front three from last weekend with Son being utilised as the out and out and striker unless it is felt that Kane is ready to come back into the fold.
Lloris, Tangana, Sanchez, Dier, Reguillon, Skipp, Hojberg, Alli, Lucas, Son, Bergwijn.
Despite being back in front of fans for the first time in well over a year, the firepower and quality that Spurs have especially with the potential return of Kane is likely to be too much for an injury-hit Wolves side.
With them not having key forces at centre back and a lack of depth going forward, the hosts are likely going to find it difficult to test out Hugo Lloris on too many occasions and the quality the away side have going forward is likely to prove to be the difference on Sunday.
What will be key for Wolves if they hope to get anything is to dominate the battle against Pierre Emile Hojberg and Skipp meaning that both Neves and Moutinho along with Leander Dendoncker are really going to have to be at their best if their side hopes to come away with at least one point.