New York (2-5), led by backup quarterback Mike White, starting in place of the injured Zach Wilson, rallied for a 34-31 win over the Cincinnati Bengals.
Indianapolis dropped to 3-5 after a 34-31 overtime loss to Tennessee, which also saw their two-game winning streak snapped.
Wilson will again be out with a knee injury for New York, who will also be without running back Tevin Coleman (knee), newly acquired Laurent Duvernay-Tardif (COVID protocol) and defensive lineman Bryce Huff (back).
Wide receiver Corey Davis (hip) is doubtful offensive lineman George Fant (ankle) is questionable. Tight end Trevon Wesco is set to return from a knee injury.
The Colts will be without wide receiver T.Y. Hilton, who has a concussion and hasn't practiced all week. Safety Khari Willis will also miss out with a calf injury.
Guard Quentin Nelson is questionable with a toe injury while cornerback BoPete Hayes is set to return from a hamstring issue.
Players to watch
Mike White (Jets)
You couldn't ask for a better first NFL start than what White did, throwing for 405 yards and three touchdowns in the win over the Bengals with his jersey winding up in the Hall of Fame.
Whether he can keep it up, especially now that opposing teams have game film on him, remains to be seen, but New York has a capable backup that can lead the offense until Wilson is ready to return.
Carson Wentz (Colts)
Indianapolis isn't 3-5 because of their signal-caller, who was acquired before the season in a trade with Philadelphia. He's thrown for 14 touchdowns with only three interceptions at the halfway point of the season, but will be compromised without Hilton available for this one.
Last year, Philip Rivers led Indianapolis to a dominant 36-7 victory, throwing for 217 yards, completing 17 of 21 passes. The Colts rushed for 109 yards and held Sam Darnold to 168 yards passing.
Thursday night's game will be televised on FOX, the NFL Network and Prime Video.
Joe Buck will be the play-by-play man, Troy Aikman is the color analyst and the duo of Erin Andrews and Kristina Pink will handle sideline duties with kickoff set for 8:20pm Eastern time.