The U's will be looking to play second-tier football for the first time since the 1998-99 season, whilst the Chairboys seek a spot in the Championship for the first time in club history.
The two teams got to the final in very different ways. Wycombe cruised past Fleetwood Town, winning 6-3 on aggregate after jumping out to a 4-1 lead following the first leg.
Due to the interruption of the season, the two teams only met once on December 21st with Oxford claiming a hard-fought 1-0 victory at the Kassam Stadium. James Henry struck in the 23rd minute from close range after Wycombe goalkeeper Ryan Allsop couldn't hold onto Cameron Brannagan's shot.
Three minutes after the goal, the Chairboys were down to ten men when Adebayo Akinfenwa was sent off in a game that also featured eight yellow cards.
Neither team has any injury concerns and they both have full squads to choose from. The only change to either side is Oxford striker Matty Taylor being inserted into the starting lineup after coming off of the bench in the second leg of the semifinals.
Oxford United (4-3-3): Eastwood; Long, Moore, Dickie, Ruffels; Sykes, Rodriguez; Brannagan; Henry, Taylor, Browne
Wycombe Wanderers (4-3-3) Allsop; Grimmer, Stewart, Charles, Jacobson; Gape, Bloomfield, Ofoborh; Wheeler, Samuel, Odenyinma
Oxford manager Karl Robinson isn't worried about the style of play that got his side to Wembley, he said:
"I don't overly worry about the style of opposition. I think it can be very derogatory if we use disrespectful terms. We will analyze ourselves."
He also stated that "their style has got us to Wembley and so has ours. The one thing that is important is it's two teams with budgets in the bottom half of the league table playing in the final.
"In the years I've done this, it's as competitive a League One as you're going to come up against. It's one we're desperate to get out of and I'm sure Wycombe will be the same.
"I'm more worried about the quality Wycombe bring to a game. They have a very strong team spirit and we have as well."
Wycombe boss Gareth Ainsworth is hoping the third time is the charm after suffering Wembley heartbreak as a player and coach.
"We could be finishing this season off upsetting the record books and re-writing the history books", he said. "It would be the first time Wycombe are in any sort of level like this and it would be a proud moment for me to lead them there.
"It's a huge game, the biggest in the club's history without a shadow of a doubt. We want to make sure we take this opportunity and grasp it with both hands. Every time I've been to Wembley, it's involved Wycombe Wanderers and I've lost the other two so hopefully it's third time lucky."