The last time these sides met at the Emirates Stadium the game ended 1-1 with goals from Pierre-Emerick Aubameyang and Jamie Vardy for either side.
Arsenal were in cruise control of the game until Eddie Nketiah was shown a straight red card - allowing Leicester with a window of opportunity to turn the game around.
For The Gunners, there are three key battles on the pitch that will determine the final result of the game.
PIERRE-EMERICK AUBAMEYANG V JAMES JUSTIN
Firstly, and arguably the most important battle if Arsenal are to run out winners on Sunday afternoon is captain Aubameyang's 1v1 duel with James Justin on the left side of the Arsenal attack.
Pierre has been the subject of vast criticism from within the Arsenal fanbase as of late.
He has been left incredibly isolated on the left of Arsenal's attack against Manchester City and Liverpool in recent weeks; calling for fans to demand he is played upfront.
With the lonely one goal in his first five games and the high expectations he has set as Arsenal's talisman, it is clear that he will be looking to really get his season off and running on Sunday.
Up against The Foxes fullback James Justin, he will fancy his chances too. The young English defender begins his first full season as the first choice Foxes right-back.
More so renowned for his ability going forward; Justin will have his work cut out for him defensively if he is to deal with Aubameyang - who's danger will give the young English defender something to think about when deciding whether to bomb forward potentially leaving space in behind for the Arsenal captain to exploit.
GABRIEL V JAMIE VARDY
Another key battle for the Arsenal team to overcome if they are to come away with all three points is against the energetic and clinical Jamie Vardy.
The new Arsenal centre half from Brazil has settled like a duck to water to life in North London and has established himself as a stalwart in the Arsenal defence.
He will, however, have his work cut out for him on Sunday afternoon as he faces one of the most prolific goalscorers in Premier League history and a player who loves a goal against Arsenal in Vardy.
With 10 goals in 11 appearances against The Gunners; Gabriel will have to be at the top of his game.
Vardy is in a race to start the game as he has missed Leicester's previous two games with a niggling calk injury - but if he does, you can bet to see an interesting duel in the middle of that Arsenal defence between himself and the Brazilian defender.
JAMES MADDISON V THOMAS PARTEY
The Ghanian powerhouse had an outstanding debut in the Europa League on Thursday night against Rapid Vienna, impressing manager Mikel Arteta greatly.
He stated the newly signed midfielder from Atletico Madrid is 'ready to start'.
Towards the back end of the game on Thursday night we saw Partey having to man the midfield by himself as Arsenal pushed for a late winner and he did so superbly.
This will be the first difficult test however for the talented midfielder.
Coming up against the creativity of James Maddison in the middle of the park of, it will be vital for Partey to stifle his influence on the game if Arsenal are to win.
On the flip side; the experienced midfielders ability to break out of pressure and burst through an opposition midfield could mean the younger English creative midfielder will have to work hard tracking back with the Ghanian.
An undoubtedly decisive duel in the middle of the park. If Maddison sees more of the ball within the game he will be able to demonstrate the impressive partnership he has with his compatriot Jamie Vardy with their ingenious link up play you so often see at Leicester.
For Partey - it is business as usual. Stifling the opposition midfielders whilst utilising his ball-carrying abilities to take the game to Leicester City.