After a 2-1 away win against Rapid Wien, Arsenal will be looking to mount on that success in the clash versus Dundalk.
Both the sides return to Europa League action after losses in their respective leagues. Arsenal fell to a 1-0 loss against Leicester City at the Emirates Stadium, whereas Dundalk dropped all the points against Waterford FC, courtesy of a solo John Martin goal.
David Luiz added to Arsenal's defensive injury crisis as he came off versus Leicester. It is unknown how long the injury will leave him out for, but it is certain he will miss the Europa League tie.
Dani Ceballos returned from injury in the loss to Leicester, it looks likely the Spaniard will start, should Mikel Arteta be willing.
Runar Alex Runarsson will be hoping to replace Bernd Leno and make his Arsenal debut.
Gary Rogers is expected to make a return in goal for Dundalk, replacing Aaron McCarey.
Ones to watch
Aubameyang scored the decisive goal in the win against Rapid Wien, the forward will be looking to add to his Europa League tally against Dundalk.
Despite a five-game goal drought in the Premier League, Aubameyang is a deadly finisher and, given a small chance, it is likely he will find the back of the net.
Nelson has only made one appearance for Arsenal this season, but with The Gunner's creative problems, he may be key to Arteta's team.
The youngster enjoyed a successful loan spell at TSG 1899 Hoffenheim in the 2018/19 season. Since then, he has become Arsenal's forgotten youngster, players such as Bukayo Saka and Ainsley Maitland-Niles have shone for the London side, but Nelson's progress has halted.
Nelson has shown his potential can be unlimited, given the chance he can use the Europa League as a way of getting back to his best.
The former Watford player is one who can cause The Gunners problems. He was influential in the qualifying rounds for Dundalk, with top performances against Inter Club d'Escaldes, Sheriff Tiraspol and Ki Klaksvik. If Dundalk are to get a result at the Emirates, they will need their midfield talisman to put in a top performance.
Where to watch
The match will be shown on BT Sport 2 HD and Ultimate, with kick-off at 8pm.