Both of their previous wins ended 1-0 against Middlesbrough and most recently Luton Town. They currently sit eighth, but three points could see them enter the top six if results elsewhere go their way.
QPR fought back from 1-0 down to win 2-1 at Watford on Monday night. Charlie Austin equalised before a 90th-minute winner from substitute Albert Adomah. Another victory would be welcome for Mark Warburton's side as they look to move further away from the relegation zone.
Both teams have their deadline day loan signings available for selection. Midfielder Sam Field joined the R's from West Bromwich Albion, while Rovers recruited defender Taylor Harwood-Bellis from Manchester City.
Forward Lyndon Dykes missed Monday's game self-isolating after a family member tested positive for COVID-19, but Warburton is hopeful he will be available.
Blackburn boss Tony Mowbray has confirmed that Joe Rankin-Costello, Daniel Ayala and Bradley Johnson remain sidelined.
They are also without long-term absentees Derrick Williams and Scott Wharton.
Midfielder Jacob Davenport could return for the Lancashire outfit after recovering from a minor hamstring strain.
Dieng; Dickie, Cameron, Barbet, Kane, Ball, Johansen, Wallace, Chair, Bonne, Austin. (3-4-1-2)
Kaminski; Nyambe, Lenihan, Branthwaite, Douglas, Downing, Travis, Rothwell, Elliott, Armstrong, Brereton. (4-3-3)
Ones to watch
Charlie Austin - QPR
A fan favourite among R’s supporters after his previous spell with the club, Austin is once again proving valuable as they look to climb the table. He has two goals in four appearances since joining on loan from West Brom and will hope to add to his tally.
Harvey Elliott - Blackburn
The 17-year-old Liverpool loanee is flourishing this season. He has 12 goal contributions so far, with four goals and eight assists. His creativity could prove essential to Rovers in their bid for promotion.
The last meeting between the sides in November ended 3-1 in Blackburn's favour. Top scorer Adam Armstrong scored twice, with Ben Brereton netting the opener before Dykes levelled from the spot.
They were both victorious in their home fixtures last season against one another, with QPR winning 4-2 and a 2-1 win for Rovers.
Earlier in the season...
How to watch
The match starts at 15:00 GMT and is available to watch for £10 via iFollow. Passes can be purchased here.
What the managers have said
Warburton is hoping his side can build on their win at Vicarage Road but is aware of the quality Blackburn have at their disposal.
"Blackburn go about their work under the radar. They have a tremendous squad put together by Tony Mowbray, who is an outstanding manager, and they are very dangerous opponents," he told the QPR website.
"On Saturday, we'll need to show the same quality in the box that we did on Monday [at Watford] to finish our chances. We went to Blackburn earlier this season and were guilty of missing two or three big chances. We can't do that at the weekend."
Mowbray wants Rovers to take advantage of the R's poor home form but believes they have players capable of causing his team problems.
"They have the boy [Ilias] Chair in midfield who's a really talented footballer, Charlie Austin's turned up there and he can score goals at this level," he told rovers.co.uk.
"They haven't been as strong at home as they have been away from home, we accept that.
"So we will try to be positive, play on the front foot and ask questions of them.
"But if we get it wrong they have good players who can pick passes and hurt us, so we have to try and focus, concentrate on our game and stick to the plan."