Boro suffered their first league defeat of the season on Wednesday. Neil Warnock's men lost 3-2 at home to Queens Park Rangers despite the visitors having Moses Odubajo sent off when the score was 1-1.
Both sides have four points from their opening three games, with Middlesbrough sitting 10th and one place above Derby on goals scored.
Boro could still be without Marcus Tavernier and Duncan Watmore due to their respective injuries.
Sammy Ameobi has yet to feature since joining the club and remains sidelined due to a knee injury.
New signing Toyosi Olusanya will travel but is unlikely to be named in the match-day squad.
Roos; Byrne, Jagielka, Davies, Buchanan; Bird, Shinnie; Sibley, Morrison, Jozwiak; Baldock.
Lumley; Dijksteel, Hall, Fry, Bola; Howson, McNair; Spence, Crooks, Jones; Ikpeazu.
Ones to watch
Louie Sibley - Derby
Sibley scored five goals and provided two assists in his breakthrough season with the Rams in 2019/20, including a hat-trick in a 3-2 win at Millwall. He made 30 appearances last season but only started 10 of those, managing to find the net just once.
The 19-year-old made his first league start of this campaign against Hull and put in an impressive performance. Rooney is pleased with how he's performed so far this season - he must now do it consistently to keep his place in the team.
Isaiah Jones - Middlesbrough
Jones has had a fine start to his first season in the Championship, having already registered two assists. He showed great determination to win possession back before assisting Matt Crooks' goal against QPR, and it was his pace that caused Odbubajo's sending off. Nathan Byrne could be in for a difficult afternoon.
Middlesbrough beat the Rams 3-0 in the reverse fixture, while their last away victory came in April 2018.
Most recent meeting:
How to watch