With Luke Shaw being the only fit player in the position in the England squad at the moment, the opportunity may arise for Mitchell to earn his first, well-deserved call-up.
The England boss has already stated his delight at the array of options he has in the left-back role, giving Mitchell a lot of praise.
"Tyrick, we've been really impressed with, he was very close [to a call-up]," Southgate said last week. "I think he's been very good with his defending, he gets out quickly to people and in the biggest games against top opponents, he's coped really well.
"Look, who knows - we could have changes over the weekend and he's one in our thoughts."
His England chance looks inevitable
The defender, who has failed to look out of place in any Premier League fixture so far this time out, helped The Eagles secure a trip to Wembley Stadium in the FA Cup semi-finals on Sunday afternoon, keeping Everton restricted to half-hearted efforts.
Ben Chilwell and Kieran Trippier are both ruled out of the international ties over the forthcoming weekend, presenting Tyrick Mitchell with the perfect chance to embed his presence in the England lineup if he is handed the chance.
Alongside the recently called-up Marc Guehi, Crystal Palace have looked effective from playing out of the back under Vieira's more positive approach to football, something that could further persuade Southgate to look towards South London for inspiration.
The Three Lions setup relies heavily on being confident on the ball and compact when on the backfoot, so Tyrick Mitchell is the perfect solution in many ways. His crosses into the box are also an addition to his game that Southgate may look to bring to the forefront for England.
Whether Mitchell gets the call-up this week or not, his inevitable England journey will happen at some point, regardless. As the young fullback continues to shut down the Premier League's superstar wingers when they arrive at Selhurst Park, his hard work will eventually pay dividends.