Both teams are fighting to maintain their top-flight status with the Whites in 16th, six points clear of the relegation zone while the Hornets are second from bottom, six points away from safety.
The Hornets have no fresh injury concerns ahead of this crunch clash with the club receiving good news on winger Kwadwo Baah, who was back in training with the first team after recovering from an ankle injury.
Joe Gelhardt looks to be available after picking up a knock in a U-23 match on Monday.
Tyler Roberts, Jamie Shackleton, Junior Firpo and Patrick Bamford all remain out.
Watford: Foster; Kamara, Samir, Kabasele, Femenía; Kucka, Louza, Sissoko; Hernández, Dennis, Sarr
Leeds United: Meslier; Dallas, Cooper, Llorente, Ayling; Forshaw, Phillips; Harrison, Rodrigo, Raphinha; James
Ones to watch
Emmanuel Dennis (Watford)
The Hornets are the fourth-lowest scoring team in the Premier League with just 29 goals to their name, but the Nigerian has accounted for nearly a third of them, finding the back of the net nine times, proving to be their only consistent scoring threat on the season.
Daniel James (Leeds United)
The former Manchester United youngster continues to be employed in a lone striker role in the absence of Bamford and will need to continue his solid play if the Whites are to continue their recent good form.
In October, Leeds ran out 1-0 winners at home to pick up their first victory of the season after a six-match winless run to begin their campaign.
Stuart Dallas forced an early save out of Hornets goalkeeper Ben Foster, who also denied Daniel James on the rebound.
James then fired well over after being set up by Mateusz Klich and in the second half, blazed high into the stands after being left unmarked at the edge of the box.
Diego Llorente, back from a hamstring injury, took advantage of a corner bouncing off of Watford's Juraj Kucka to poke home and give the Whites all three points.
How to watch
The match was not selected for live broadcast coverage, but LUTV will provide live commentary for Leeds supporters while www.watfordfc.com/live has live commentary for Watford supporters.
Kick-off is set for 3pm UK time.