The Seattle Sounders host the Vancouver Whitecaps at Lumen Field in the first of two Cascadia clashes this season.
Seattle plays the second of five consecutive matches at home with their first a victory over Charlotte, but the Sounders still sit 11th in the Western Conference.
For Vancouver, they are finding their best form in recent weeks, having won four of their last six matches, but are winless in their last 14 matchups against Seattle.
Team news
The CONCACAF Champions League winners could be without Cristian Roldan, Jordan Morris, Albert Rusnak and Xavier Arreaga, who are all either on or returning from international duty.
Joao Paulo continues to be a long-term absentee with an ACL tear while backup goalkeeper Stefan Cleveland is a doubt due to a laceration on his face. Yeimar Gomez has a right hamstring issue.
Much like Seattle, Vancouver could be without key players due to international commitments as the status of Lucas Cavallini, Javain Brown and new signing Andres Cubas are all up in the air.
Thomas Hasal is a long-term casualty due to a hand injury, Cristian Gutierrez is also set to miss out with a calf problem.
Russell Teibert is a doubtful with an eye issue and Cristian Dajome may miss out with tightness in his hamstring.
Predicted lineups
Seattle Sounders: Frei; Nouhou, Arreaga, Ragen; Medranda, Rowe, Lodeiro, Vargas, C. Roldan; Chu, Ruidíaz, Dobbelaere
Vancouver Whitecaps: Cropper; Nerwinski, Godoy, Veselinovic; Blackmon, Jungwirth, Owuhu, Berhalter, Raposo; White, Caicedo
Ones to watch
Raul Ruidiaz (Seattle Sounders)
The Seattle star striker has re-discovered his form and loves playing Vancouver, scoring six times in seven career matches against the Sounders' Cascadia rivals.
Ryan Gauld (Vancouver Whitecaps)
With Cavallini, Vancouver's best player, away on international duty, much of the spotlight will be on the Whitecaps' Designated Player, who has two goals and two assists in 677 minutes this season.
Previous meeting
On Decision Day last year, the two sides played out a 1-1 draw in Canada.
Fredy Montero converted an eighth-minute penalty that Cristian Roldan drew, sending Vancouver goalkeeper Maxime Crepeau the wrong way.
The Whitecaps equalized in the 20th minute as Ryan White sent a ball across the box that Ryan Gauld headed home.
How to watch
The match will be streamed nationally on ESPN+. In Seattle, coverage will be provided by FOX 13. TSN1 has all of the action in Vancouver.
Kickoff is set for 10:30pm Eastern time.