Spurs can get their outside Champions league run back on track after being held to a 1-1 draw against rivals Manchester United on Friday.
West Ham, 17th in the league, are only surviving the bottom three on goal difference after falling 2-0 to Wolves.
Albeit a tough ask, they will desperate to get some breathing space and beat their bitter rivals.
This long-standing derby is usually producing an electric atmosphere. But with no fans, the game will be a strange spectacle.
Defenders Japhet Tanganga and Juan Foyth remain side-lined.
West Ham centre-back Angelo Ogbonna has returned to training and is being assessed, while Sebastian Haller again looks set to miss out, as does Robert Snodgrass due to an ongoing back issue.
Last time they met
The last time these rivals clashed, Spurs ran out 3-2 winners in Mourinho’s first game in charge at the London Stadium.
Mourinho’s men blew the Hammers away in the first half, but Ogbonna and Antonio’s late goals made it a nervy ending.
In general, Spurs are a mixed bag when it comes to West Ham. In the last six encounters, they’ve won two, drawn one and lost two.
The return of Lucas and Dele is a massive boost to Spurs, who are searching for their first Premier League win in four matches.
They need to overcome this match with a victory in order to put any fight up for a Champions League spot, which could be fifth place.
However, West Ham are desperate for points and will try everything to cause an upset against their big rivals.
Both teams need the points for their own reasons, which should make the game an intriguing match.