The Potters have since slipped to tenth place and are in dire need of a win against the relegation threatened Owls, who had their previous game against Swansea called off due to a frozen pitch.
Wednesday's form has picked up in recent weeks, with many backing caretaker boss Neil Thompson to stay in the job permanently.
Stoke will be without highly-rated defender Nathan Collins for the game, after he was stretchered off in the final minutes of their defeat in Norfolk.
Michael O'Neill has since confirmed that Collins damaged his metatarsal, and the 19-year-old is expected to be out for a number of weeks.
Goalkeeper Adam Davies remains sidelined after a recent setback to his recovery from a hamstring injury.
Rhys Norrington-Davies is still suspended following his red card against Huddersfield Town, while striker Tyrese Campbell continues to be sidelined after suffering a season-ending knee injury in December.
Wednesday have numerous injury concerns heading into their visit to the Potteries.
Despite Andre Green coming back into the fold after a knock to his achilles, both Massimo Luongo and Joost van Aken are likely to miss out in the coming weeks with injuries.
Stoke City: Gunn; Smith, Souttar, Chester, Fox; Cousins, Clucas, Allen; Clarke, Fletcher, Powell.
Sheffield Wednesday: Westwood; Lees, Dunkley, Urhoghide; Harris, Shaw, Hutchinson, Bannan, Reach; Paterson, Rhodes.
Ones to watch
The 26-year-old attacking midfielder has been the Potters’ main creative outlet this season, chipping in with eight goals and two assists so far in a side that severely lacks goals. After the loss of talisman Campbell in December, Crewe-born Powell has been the man to step up and provide goals in key moments for City.
Michael O'Neill has deployed the Englishman on the left side of a front three in recent months, but Powell's preferred position is just behind the striker. Stoke will need both him and former Wednesday man Steven Fletcher to be firing if they are to improve their goalscoring form in this game.
The Scotland international has been in good form since being moved back to striker by interim boss Thompson, with four goals and one assist in his last seven league games. Goals have been hard to come by for Wednesday this season, with the Owls scoring just 21 in the Championship so far, but 27-year-old Paterson has found his scoring touch at a vital time in the battle for survival.
Both Paterson and experienced strike partner Jordan Rhodes will fancy their chances against a Stoke defence that looked shaky and leaked four goals last time out against Norwich.
The two played out a bore 0-0 draw at Hillsborough in the reverse fixture earlier this season, but the last game between the two at the bet365 Stadium was far from dull.
Wednesday had seemed to be edging out a 2-1 win on Boxing Day 2019, but goals in added time from Tyrese Campbell and Sam Vokes clinched a late Christmas present for the Potters fans.
Since Stoke's relegation to the Championship in 2018, things have been equally balanced with three draws and one win apiece in five games between the two.
How to watch
The game will kick off at 7pm on Wednesday February 16 and is available to watch on Sky Sports Red Button or Sky Go Extra.
The game will also be available to watch on either ‘iFollow Sheffield Wednesday’ or ‘Stoke City+ Live’, with a match pass costing £10.
What the managers have said
In quotes taken from Wednesday's official website, Neil Thompson insisted that his players are not affected by the differing form of the two teams, he said:
“We know the run they’re on but it doesn’t matter, this is the Championship.
“You only have to look at what happened (on Saturday), Wycombe are 2-0 down at Huddersfield and turn it around to win 3-2 and suddenly Huddersfield could be looking over their shoulders.
“We have a big week ahead of us. We have Stoke on Tuesday and Birmingham on Saturday and that’s a game that could be described as a six-pointer but you can only get three points and that has to be our aim for every game we play."