The Cottagers saw their five-match unbeaten run come to end in a 1-0 defeat to Newcastle, but still sit an impressive seventh in the Premier League table following promotion from the Championship.
Spurs took a two-goal lead against Manchester City last time out, but were undone by four straight goals from the reigning champions in a 4-2 defeat that leaves them in fifth, despite three defeats in their last four games.
Tottenham have dominated Fulham in recent matches, winning 14 of their last 16 meetings in all competitions.
American international Antonee Robinson returns to the back-line following a one-match ban served against Newcastle after picking up five yellow cards this season.
Neeskens Kebano is the only player on the Cottagers' injury list as the Congolese continues to be sidelined with a ruptured Achilles suffered in November.
Lucas Moura has been ruled out, with the Brazilian continuing to battle an Achilles issue.
Fulham: Leno; Robinson, Ream, Diop, Tete; Palhinha, Reed; Willian, Pereira, Decordova-Reid; Mitrovic
Tottenham Hotspur: Lloris; Lenglet, Dier, Romero; Sessegnon, Bentancur, Højbjerg, Doherty; Richarlison, Kulusevski; Kane
Aleksandar Mitrovic (Fulham)
The Serbian is again leading the line for the Cottagers, having scored 11 goals in 16 appearances, which equals his best showing in the five Premier League seasons he's played in.
Mitrovic's issue is from the penalty spot, having had his spot-kick ruled out last week following his foot touching the ball twice after slipping, the third time he has failed to convert.
Harry Kane (Tottenham Hotspur)
The Spurs star man sits two goals away from reaching 200 in the top-flight and his next goal will tie Tottenham legend Jimmy Greaves' mark of 266.
Kane has also been lethal in North London derbies, scoring 14 times in 18 appearances against sides from the English capital.
Where is the match being played?
Craven Cottage will play host to this London derby.
What time is the match?
Kick-off is scheduled for 8pm BST.
How can I watch the match?
Sky Sports Premier League will have all of the action with coverage scheduled to begin an hour prior to kick-off.