In their last Premier League game, Southampton were 3-0 victors over Leicester.
Luciano Narsingh could make his Swansea debut, after recovering from the calf injury that forced him to miss the win over Liverpool.
Jefferson Montero will miss another game because of a hamstring injury that has kept him out of the last four games, while Paul Clement has also revealed that Leon Britton is unavailable but Ki Sung-Yeung is fit again.
Southampton are without star man Virgil van Djik due to an ankle injury, while James Ward-Prowse, Jay Rodriguez and Steven Davis are all doubts.
Swansea boss Clement said: “It’s really important to back up what we did at Liverpool with another good performance.”
Clement also said that his side has to be better and more consistent at home, and that away wins against the big teams are just a bonus.
Speaking about the opposition, Claude Puel said: “They have a new manager and they have quality. They are strong in defence. It’s a difficult team to play.”
Puel also implied that there will be heavy rotation from the lineup that played against Arsenal.
Earlier in the season, Southampton beat Swansea 1-0, courtesy of a Charlie Austin volley, giving manager Puel his first Premier League win of the season at the fifth attempt.
Southampton did the double over Swansea last season, winning 1-0 at the Liberty Stadium and 3-1 at St. Mary’s.
Swansea have only beaten Southampton once in their last seven meetings, coming from a Jonjo Shelvey stunner in 2015.
The fixture kicks off on Tuesday, 19:45 at the Liberty Stadium.