Lee Bowyer's Charlton Athletic sit just one point above the bottom three going into this weekend's fixture.
Their last match resulted in a 2-1 defeat to high-flying Brentford at Griffin Park.
Striker Macauley Bonne gave the visitors the lead but two late goals from Said Benrahma and Ethan Pinnock saw the hosts claim the three points.
It finished 0-0, with neither side doing enough to deserve the win.
Mark Bowen's side sit 13th in the table and comfortably mid-table.
Although they struggled to create many chances against the Terriers on Tuesday, Reading rarely looked like conceding.
They go into the game against Charlton on the back of two consecutive clean sheets.
Meanwhile the hosts have only scored 47, meaning that there are only two teams in the league which have scored less this season.
To make matters worse, their top scorer Lyle Taylor, with 11 goals, is no longer playing for them as he wishes to move on.
For Bowyer's side to have any chance of winning on Saturday, and staying up in the long run, they need to start scoring more goals.
A win for Charlton at the Madejski in August propelled the newly promoted team into an automatic promotion spot, albeit temporarily.
Goals from Jonathan Leko and Taylor made it a comfortable afternoon for the Addicks, although it has been mainly downhill ever since.
The then Reading manager Jose Gomes lasted just two more months in charge before Welshman Bowen took over for what has been an unpredictable season for the Royals.
Charlton will check on the fitness of winger Andre Green before the game, whilst full-back Lewis Page has returned to training.
For Reading, Ovie Ejaria and Andy Yiadom are still likely to miss out through slight knocks.
However USA international Matt Miazga can return from his three match suspension.
Former England international Bowyer is aware of the threat Reading possess, but feels it is a good opportunity for his struggling side to pick up a much-needed victory.
"Reading are another good side but it’s a game where I think if we turn up and do things right, we’ve got as good a chance as they do. The most important thing is that we keep fighting, pushing and sticking together until the end."
Similarly, Reading boss Bowen is expecting a tough afternoon.
"It’ll be a difficult game, Charlton. I watched them play against Millwall the other night and they’re a force on their own ground, a difficult side. They got beat on the night but they were the better side, believe me.
“We’ve got enough to break them down if we do things right on the day and if our quality is better.
“But they’ll ask questions of us. They went up against Brentford away from home on Tuesday. It’s there to see – what can happen if we take our eye off the ball, treat them lightly. I fully expect a hard and difficult game against Charlton and we have to be fully prepared for that.”