Both teams are coming off of the back of draws in the Premier League but the feeling in the respective camps will be very different.
Burnley will feel relieved to be up and running for the campaign after picking up their first point against West Bromwich Albion.
For Jose Mourinho and his Tottenham Hotspur side will be feeling disappointed after last week's shock 3-3 draw against West Ham United.
After being 3-0 to the good in the opening period, Spurs let the lead slip in the final ten minutes of the game and Manuel Lanzini was able to rescue a point for The Hammers.
Spurs did pick up a win in midweek in the Europa League to get their campaign off to the perfect start.
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Team News
Tottenham face a dilemma at the back as Japhet Tanganga and Eric Dier are set to miss the game at Turf Moor.
Ben Davies could keep his place at centre back after a good display in midweek, meaning that Davinson Sanchez will miss out after looking out of sorts against West Ham.
Burnley are still missing Phil Bardsley after he tested positive for COVID-19, and Erik Pieters is a doubt.
This could mean that Matt Lowton goes into the line-up after only just returning to training following an ankle injury sustained last month.
Ben Mee and Jack Cork are still out while Bailey Peacock-Farrell has been added to the injury list.
Jay Rodriguez should be fit after only being fit enough to come off the bench against The Baggies, but Sean Dyche could stick with Ashley Barnes.
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Predicted Lineups
Burnley
Pope; Lowton, Tarkowski, Long, Taylor; Gudmundsson, Westwood, Brownhill, McNeil; Wood, Barnes.
Tottenham Hotspur
Lloris; Doherty, Davies, Alderweireld, Reguilon; Ndombele, Hojbjerg, Lo Celso; Bergwijn, Kane, Son.
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Ones to watch
Dwight McNeil
It will be no surprise to see Spurs dominate the ball in the Burnley half.
Meaning that Dwight McNeil will need to be ready to use his pace to counter and hit his opponents on the break.
But not only will McNeil have to do a lot of running forward, but his final ball into the strikers will be crucial as opportunities will be limited.
Confidence will not be high after a dismal start to the campaign, but give the Clarets a chance and they will punish anyone.
McNeil is crucial to this.
The wide defenders for Mourinho’s men will be pushing forward meaning the England Under 21 International will need to be on his toes defensively as well.
Son Heung-Min
The South Korean wizard has produced magical displays this season linking up perfectly with Harry Kane all season.
And he will need to be at his technical best against Burnley who keep the pitch nice and compact throughout the 90 minutes.
His manager called him World Class this week and his performances so far have been just that, scoring goals and linking up the play with Kane.
Seven goals and two assists are the second highest goal contributions in the league only behind, believe it or not, Harry Kane.
His technical ability, speed and direct running make him the biggest threat in a very deep Spurs attack, and will cause a lot of problems for the Burnley defence.
Burnley know all too well about Son's blistering pace after he scored in the reverse tie earlier in the season.
He picked the ball up in his half and took it all the way into the area and slotted past Nick Pope.
Spurs fans will be hoping he does the same again this time around
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Previous Meeting
Burnley 1-1 Tottenham Hotspur (07/03/20)
The last time the two sides was just before the first Coronavirus Lockdown, and The Clarets produced a fine performance against an injury hit Spurs.
Chris Wood opened the scoring in the first half after Hugo Lloris spilled a Jay Rodriguez shot in the first half.
Dele Alli, who started up front in place of injured Son Heung-Min and Harry Kane, dispatched a second half penalty after Ben Mee fouled Erik Lamela.
Giovani Lo Celso and Lucas Moura really changed the game after being introduced at half time and it was Argentine Lo Celso who almost found the net late on with a curling effort from outside the box.
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Where to watch
The game is live on Sky Sports Main Event, with kick-off at 8pm.