Lucas Joao, John Swift and Andy Rinohmota eased the hosts the victory at the Madejski.
Alex Neil's hosts will remain without long-term absentees Louis Moult, Patrick Bauer and Declan Rudd.
The visitors may be without young star Michael Olise after he was taken off with a shoulder injury on Tuesday.
Long-term absentees Yakou Meite, Liam Moore, George Puscas; Andy Yiadom and Felipe Araruna are expected to be returning within the coming month.
Iverson; Browne; Huntington; Davies; Hughes; Whiteman; Ledson; Sinclair; Molumby; Barkhuizen; Jakobson.
Rafeal; Holmes; McIntyre; Morrison; Richards; Rinohmota; Laurent; Ejaria; Swift; Aluko; Joao.
Ones to Watch
Experienced Sinclair has been vital for the Lancastrian outfit this season, comfortably sitting top of the club scoring charts.
A player Reading fans know well, he famously notched a hattrick against the Royals in the 2011 Championship play-off final for Swansea City.
For Veljko Paunovic, Joao remains on a hot streak after scoring seven in seven matches either side of an injury lay-off.
He averages a goal contribution every 72 minutes, better than anyone else in the top four leagues of English football.
Dubbed 'Revenge Month' by Paunovic, Reading's four fixtures are all against sides that beat the Royals in the first half of the campaign.
Preston comfortably won 3-0 in Berkshire, with goals from Sinclair, Brad Potts and Emil Riis Jakobson.
Overall the sides have met 62 times, with 25 wins apiece heading into Sunday's fixture.
"I am not sure it was a 3-0 game. We played well, were a threat and got our goals at the right times, but equally they had some chances in the game.
"This one is going to be tough. They have got some players back who weren’t available at that point, which makes them stronger, so it is going to be a tough match.
“They are a good side, aren’t they? They have spent a lot of money on a lot of players. They have got a lot of guys who can’t even get into the team, in particular, the attacking options that they have are a big, big threat and you could see that the other night against Coventry, because Coventry played well and lost 3-0.”
Meanwhile Serbian Paunovic is calling on his players to refocus after their comfortable win in midweek, and prepare fully for Sunday's test.
"Now we focus – and I know that I am repeating myself here as it is the same each time – but we have to recover from our big effort in midweek and prepare ourselves for another tough game.
“It is an opponent that beat us in the past. So it’s our time to see if we are capable of again putting in another good performance and get a win.”
How to watch
The game is being showed live on Sky Sports Football on Sunday from 12pm, and so will be unavailable on iFollow.