The Robins are currently third in the table, and come into the game full of confidence, following a 1-0 victory in midweek over table-toppers Cambridge United.
Emmanuel Onariase will be assessed ahead of the game - the defender missed Tuesday's game at Bolton with a groin strain but has trained this week.
Aaron Jarvis, Olufela Olomola and George Hornshaw all remained sidelined for the home side.
As for Cheltenham, their injury list grows by the week, with Chris Hussey hobbling off in the second half of Tuesday's victory with a dead leg.
He joins Charlie Raglan, Will Boyle, Liam Sercombe, Alex Addai, Ellis Chapman and Chris Clements currently out of action.
Howard; Brown, McGahey, Taft, Clarke; Eisa, Beestin, Karacan, Gillead; Loft, van Veen.
Griffiths; Tozer, Horton, Long; Blair, Chapman, Thomas, Azaz, Hussey; May, Smith.
Ones to watch
Scunthorpe's masterful Dutchman has had a horrid injury ridden campaign, but has recently began to edge his way back into Neil Cox's starting XI. With two substitution appearences in recent weeks - van Veen could be given the nod this weekend and will no doubt be a handful for the Robins backline.
With nine goals and six assists to his name this season, Alfie May has been a main-stay in this high flying Cheltenham Town side. The forward turned provider again on Tuesday evening when his superb floated cross was met smartly by Sean Long to give Town all three points.
Cheltenham were the victors earlier this season, Michael Duff's side struck early thanks to a Rueben Reid penalty to deny Scunthorpe a share of the spoils.
Where to watch
The game kicks off at 15:00 on Saturday 27th February 2021.
It will be streamed on both clubs’ iFollow channels, available to purchase for £10.