Although initially announced as interim boss, the former Real Madrid centre-back has been given the gig on a permanent basis.
His Cherries side still remain in the play-offs by one solitary point in sixth place.
However, Barnsley are the team behind them in the standings and the Reds have one game in hand over Bournemouth with only one point separating them.
Bristol City are currently 11th, but as the result of a congested race for the play-offs, the West Country side are only seven points off of the Cherries themselves.
A familiar story for the home side has been injuries this season and Bristol City are set to be without a host of personnel again for this fixture.
Defenders, Alfie Mawson and Jay DaSilva are set to be sidelined alongside Chris Martin, Tommy Rowe Callum O'Dowda, Hakeeb Adelakun, Henri Lansbury, and Andreas Weimann.
For Bournemouth, the injury list is not as extensive but David Brooks and Jack Stacey are set to sit this one out due to injury.
Bristol City (3-5-2): Bentley, Vyner, Kalas, Mariappa, Hunt, Nagy, Bakinson, Massengo, Hunt, Wells, Diedhiou.
Bournemouth (4-3-3): Begovic, Smith, Carter-Vickers, Cook, Kelly, Cook, Pearson, Lerma, Stanislas, Solanke, Danjuma.
Under Nigel Pearson, Bristol City's fortunes look to be changing following two impressive away victories against Middlesbrough and Swansea - both in the top six.
An impressive 1-0 victory over Watford on the weekend is an encouraging sign for the side.
But the same can best be said of their opponents last game with their 3-1 victory over Swansea.
Ones to watch
Bristol City have scored six goals in their last two games, compared to three in the eight league games prior.
Nahki Wells scored one in both of the last two and looks to be showing glimpses of his capabilities that he so often showed prior to his move to Ashton Gate.
Rejuvenated under Pearson, Wells has the capabilities to cause any team a few problems on his day with his shooting skills and vast experience in the division.
Dominic Solanke is Bournemouth's top goalscorer this season and prior to the last match against Watford had a spell on the sidelines.
Now with a full 90 minutes back the English forward is no doubt closer to being fully match-fit, having lasted 80 minutes last time out.
The former Liverpool striker has shown his ability this season to be considered one of the league's best and he will have to quickly find a return to form to booster his side's promotion hopes.
October was the last time these two faced off in what was a 1-0 victory for the Cherries.
An 81st-minute goal from Aranut Danjuma was enough to seal the affair following a fairly dull game with only six shots on target combine from both teams.
Outside of this current season, baring a friendly in the summer of 2018 and 2013, these teams both played each other last in 2006 in League One.
That game finished 2-2 on the Cherries’ turf with goals Carl Fletcher, and James Hayter for Bournemouth. And Leroy Lita and Jamie Smith scoring for Bristol City.
Where to watch
The Championship clash will be available on the Sky Sports red button with kick-off at 19:45 on Wednesday, whilst you can check out the report here on VAVEL.