Leeds United announced last night that Kalvin Phillips has been ruled out for up to six weeks with a shoulder injury that was sustained during Monday night's match against Wolverhampton Wanderers at Elland Road.
According to Leeds, the England international will not require surgery but could still be sidelined for a while, adding to the Whites' injury worries.
Phillips began his rehab yesterday morning at Thorpe Arch where he is working with the medical team to get back on the pitch as quickly as possible.
What games will he miss?
Next up for United is Aston Villa away on Friday night, where Phillips has previously been tasked with man-marking Jack Grealish.
In the Championship seasons before promotion to the Premier League, Phillips was key in nulling the threat made from Grealish.
The home-grown talent will likely also miss games for his club against Leicester, Crystal Palace, Arsenal, and Everton.
After winning his fourth cap for England over the last international break, it seems that the 24-year-old will also miss the final two Nations League group stage games.
England currently sit in third in their league and need points from their final two games against Belgium and Finland to progress.
Who can replace him?
Marcelo Bielsa has previously come out and said that either Robin Koch or Pascal Struijk can play in Phillips' deep-lying midfielder position.
However, with captain Liam Cooper, Diego Llorente, and Gaetano Beradi all sidelined with injuries themselves and no further centre-back cover it could prove problematic.
It's possible that the defensive line-up could be reshaped to push either Koch or Struijk forward into the defensive midfielder position.
This could see the likes of Ezgjan Alioski being brought into left-back, Luke Ayling moved into centre-back and Stuart Dallas possibly pushed over to the right.
Adam Forshaw is a natural replacement for Phillips but also suffering a long setback with an injury.
Jamie Shackleton could make his full Premier League debut after appearing as a substitute at Anfield against Liverpool in Leeds' 3-4 loss on the opening weekend of fixtures.