Both teams head into this game in terrible form and know that there is more than just local bragging rights at stake on derby day.
Just five points have been taken in total between both teams in their last six games each, with the visitors Grimsby languishing in the relegation zone and only team separating them from Scunthorpe.
Paul Hurst will be desperate for the first win of his second spell as Grimsby manager, and now would be the perfect time to do it coming up against his previous employers.
However, The Iron will be searching for some revenge of their own having lost the last two meetings between the two clubs.
For Scunthorpe, technical left-back Junior Brown is suspended after his red card at Barrow, which means Mason O'Malley could start.
Athletic defender Manny Onariase made his return last time out and could come in here for Harrison McGahey.
The "pantomime villain" of this fixture Kevin Van Veen will be out for another two months with a hamstring tear.
For the visitors, target man James Hanson misses out, though winger Sean Scannell returned from the bench in the previous game, with Hurst likely to stick to a 4-4-2 which produced a clean sheet last time out.
Scunthorpe United (4-3-3):
Howard; O'Malley, Taft, Onarise, Clarke; Spence, Karacan, Beestin; Eisa, Loft, Gilliead.
Grimsby Town (4-4-2):
McKeown; Hendrie, Waterfall, Pollock, Habergham; Wright, Spokes, Hewitt, Scannell; Green, Williams.
Ones to watch
Scunthorpe United – Abo Eisa
Eisa has arguably been the Iron’s best performer this season, topping both scoring and assists charts for the club this season.
It would not be a surprise to see the midfielder injected into the starting lineup on Saturday after starting on the bench in the 1-0 defeat to Barrow last week.
Grimsby Town – Rollin Menayese
The 6’3” central defender became Hurst’s second signing of the January window on January 18, signing on-loan from Mansfield Town until the end of the season.
The defence is where Town have been in desperate need for reinforcements, and we could see Menayese make his debut on Saturday, depending on what system the Grimsby manager opts for.
The game threatened to spring into life on a couple of occasions but never really got going as The Mariners saw out what is still their most recent victory.
How to watch
To view this game, you will have to purchase a £10 'iFollow' match pass on either of the club’s official websites.
What the managers said
Scunthorpe manager Neil Cox expects a much-improved performance from his side compared to their first meeting with Grimsby last month.
“We’re looking forward to it and it’s probably the biggest derby game we’ve had in a long time,” he said, speaking to iFollow Iron.
“Both clubs are at the wrong end of the table so there are three massive points up for grabs.
“We will definitely be a different side - the way we react and the way we’re going to battle,” he continued.
“We’re going to fight and play forward and have a little bit more quality. We want to be really positive in the way that we play our game."
Grimsby boss Hurst expects more transfer activity in the coming week as he looks to prepare his squad for a tough relegation battle.
Speaking to GrimsbyLive, Hurst said: "We're just continuing to talk with one or two. Some have been ruled out, and I am certainly hoping to add to the squad before the window closes.
"It's not a case of we've got a couple and that's it. We'll continue those talks, probably put it to bed in the main until we get Saturday out of the way."