Following a rather dull 0-0 affair last Sunday, Ole Gunnar Solskjaer's side will have a point to prove as they look to progress to the next round of the competition.
This time out there will be a winner with extra time and penalties on the cards if the game ends level pegging.
It is mainly positive on the injury front for Man United with no fresh injury concerns heading into this tie. Victor Lindelof looks fit to play after being given a rest midweek following the Premier League clash with Liverpool.
Jurgen Klopp's team are not so lucky when it comes to injuries with a whole host of first-team players missing. Long-term absentees Joe Gomez and Virgil van Dijk remain out of action alongside Naby Keita and Diogo Jota.
Recent makeshift centre-back Jordan Henderson is a doubt having missed the game against Burnley with a muscle injury, but Joel Matip returned to the heart of the defence in his place.
United: Henderson, Wan-Bissaka, Lindelof, Maguire, Telles, McTominay, Fred, Van de Beek, Fernandes, Rashford, Martial.
Liverpool: Alisson, Williams, Matip, Fabinho, Tsimikas, Jones, Thiago, Wijnaldum, Salah, Firmino, Mane.
Ones to watch
Bruno Fernandes is due a great performance against 'Big six' opposition and when better to show up than a game against Liverpool.
United's talisman struggle last time out against Klopp's team and has only managed three penalty goals and two assists in ten appearances against the traditional top six teams and as good as he has been since his arrival, Solskjaer does need more from his star in the big games.
This game could be the catalyst for the midfield maestro to kick on and show rivals what he's made of.
As for Liverpool, the player to watch could really be anyone with there majority of their key players to perform as of late. The front three of Mohamed Salah, Roberto Firmino and Sadio Mane will be itching to grab their first goals of 2021.
The United defence performed excellently to keep their opponents at bay in the last meeting, but you can never write Liverpool's front three off and they are always going to be dangerous.
Head to head
The Red Devils have failed to get the better of their rivals in the last five games with three draws and two defeats. However, they do have the better form overall over the past five games having recorded three wins, a draw and a defeat while Liverpool have just one win alongside two draws and two defeats.
An interesting stat between the two clubs is Liverpool have been eliminated from the FA Cup by United more times than any other club and the overall head to head in the competition is nine United wins, four draws and four Liverpool wins.
Manchester United 1-1 Liverpool (United to win on penalties).
Where to watch on TV
The match will be shown live on BBC One with kick-off at 5PM.