Bournemouth will be looking to get their first win in three matches after losing to fellow play-off contenders Barnsley 3-2 on Saturday.
Swansea City come into the game on a high after beating Luton Town 1-0 at Kenilworth Road.
The Cherries sit in seventh place, five points adrift of Barnsley after their loss at the weekend. The Swans are in third and outside the top two on goal difference but do have a game in hand over Watford.
Central midfielder Lewis Cook could miss the rest of the calendar year after suffering another serious ACL injury.
He will be joined on the sideline by fellow midfielder David Brooks after his latest injury saw him miss out on Wales selection.
Jordan Morris and Liam Cullen will both be missing Tuesday's game and the rest of the season with knee and ankle injuries respectively.
Marc Guehi is an injury doubt after picking up a groin injury and faces a late fitness test to see if he can play any part on the South Coast.
Begovic; Smith, Cook, Carter-Vickers, Kelly, Wilshere, Pearson, Lerma, Stanislas, Solanke, Danjuma.
Swansea City (3-4-1-2):
Woodman; Latibeaudiere, Bennett, Cabango, Roberts, Grimes, Fulton, Manning, Hourihane, Ayew, Lowe.
Ones to watch
The Dutchman only made six appearances in an injury-hit first season after joining from Club Brugge. The relegation from the Premier League meant Bournemouth had to be strict with their spending allowing Danjuma to get his chance.
This season in his 24 games, the winger has scored nine goals and assisted on three occasions. The 24-year-old has started well in the Championship but must keep his performances up in order to keep his place in the side with Junior Stanislas also in fine form.
The 29-year-old midfielder was a hit in the Championship for Aston Villa in their promotion-winning season. The Irishman scored seven times from central midfield and played a key part for Dean Smith's side.
This season has been no different for Hourihane at the Swans. In his 10 league appearances for the Welsh side, he has scored five times and laid on one assist in the process. His wand of a left foot holds the key to unlocking many defences and is a major asset to Steve Cooper's side.
The two sides previously met back in December with the game ending 0-0 at the Liberty Stadium.
The last time the two sides played each other at the Vitality was in the Premier League with the Cherries winning 1-0 thanks to an early goal from Ryan Fraser.
The Swans have failed to score against Bournemouth in the previous six meetings.
Last time out...
How to watch
Due to the current national lockdown, no fans will be in attendance at the Vitality Stadium. This means the game is available on iFollow through Bournemouth and Swansea's respective club websites, with passes being priced at £10.
The game is also available on Sky Sports Main Event.
The game kicks off at 19:45 GMT on Tuesday 16 March 2021.