Michael Appleton's Imps will be looking to end the regulation season with three points after failing to win their last three games.
Although the pressure is off knowing that a top six spot is already in the bag, the Lincoln boss will be keen to head into the playoffs on the back of a win.
The Dons can also play with freedom having secured their League One status last Saturday, despite a 3-1 home defeat to Portsmouth.
Lincoln City defender Adam Jackson returns to the squad following a mystery injury that the club still hasn't got to the bottom of, whilst Brennan Johnson is close to full fitness and is likely to play some part.
Anthony Scully is a major doubt, however, after limping off against Charlton Athletic in midweek, whilst defender TJ Eyoma has a knee problem and won't be risked.
For AFC Wimbledon, meanwhile, centre back Ben Heneghan misses out due to a hamstring injury.
Ones to watch
Lincoln's Jorge Grant will be looking to add to his tally of 15 for the season now that he's returned to full fitness.
The midfielder missed six weeks of the end of season run-in and has been eased back into action over the last few games.
Ollie Palmer will lead the Dons' attack against the side for whom he played for in the 2017-18 season, scoring eight goals.
Captain Alex Woodyard, who was a key member of the Imps' National League success in 2016-17 will also want to get one over his former employers.
What the managers have said
Lincoln boss Michael Appleton told the press he has challenged his players to perform well in order to earn starting places in next week's crucial play-off games.
"Our motivation is that we hopefully have three games left to play," he said.
"The players know a good performance tomorrow could get them in the starting line-up for the play-offs.
"Mark Robinson has done a fantastic job at Wimbledon, and they'll play with freedom and enjoyment knowing they are safe."
Wimbledon manager Mark Robinson told his club's website that he will probably resist giving fringe players a starting berth, as he wants to give his side the best possible chance of ending the season with a victory.
"It’s a difficult one, and it’s something I have to think about," he said.
"If I bring players into the side I will feel I’m not rewarding the lads who have done really well to get us out of the situation we were in.
"By the same token I realise that fans might want to see players who haven’t had opportunities. It’s something for me to think about, but it has been a squad game anyway. We will probably be looking just to continue our form with the players who have mainly been involved."
Lincoln (4-3-3): Palmer; Poole, Jackson, Montsma, Edun; Grant, Bridcutt, McGrandles; Anderson, Hopper, Rogers.
Wimbledon (4-4-2): Tzanev; Alexander, O'Neill, Nightingale, Guiness-Walker; Assal, Woodyard, Rudoni, Dobson; Palmer, Pigott.
Lincoln emerged victorious from January's reverse fixture, with Tayo Edun and Tom Hopper securing a 2-1 win.
Ollie Palmer scored the Dons' goal, meanwhile.
How to watch
The game kicks off at 12:00 BST on Saturday. The game is available on each club’s respective iFollow service, priced at £10 for UK viewers and £7 for international fans.