Reading are in great form themselves, only losing one of their last seven games, winning five of those, including most recently a 1-0 win over Barnsley on Saturday afternoon.
Reading are currently in an injury crisis, having more than eight first-team players out with injuries, with the likes of Lucas Joao, Yakou Meite, Michael Morrison and Alen Halilovic amongst them. Andy Rinomhota may return if he passes a late fitness test.
Blackpool also have a number of players injured at the moment, with the likes of Daniel Gretarsson, Shayne Lavery and Grant Ward all out. Dujon Sterling and Keshi Anderson should both return to the squad after missing Saturday's game, however Kevin Stewart is still being assessed after hobbling off during Saturday's game.
Southwood; Yiadom, Dann, Moore, Baba, Drinkwater, Laurent, Dele-Bashiru, Swift, Ejaria, Puscas.
Grimshaw, Sterling, Keogh, Ekpiteta, Garbutt, Dougall, Wintle, Bowler, Anderson, Yates, Madine.
Ones to watch
The midfielder has arguably been the best player in the league this season, with 13 goal contributions in 12 games. If he carries on his form, who knows where the Royals could end up this season.
With the absence of Lavery, Blackpool will need a player to step up in his absence, and Anderson is that man. With his sheer pace and dribbling ability, he can really bring the team forward and provide another great attacking option.
How to watch
This game kicks off on Wednesday, October 20 at 20:00 BST, and is available to watch on Sky Sports Red Button.