Brentford had an impressive start to the season under Thomas Frank after infamously conquering Arsenal on the opening day, sparking solid performances.
They sit 14th now but are growing ever more fearful of the drop zone with the gap only being four points from the bottom three, with Burnley having three games in hand on them.
Newcastle on the other hand will be confident of extending their unbeaten run to eight games after a valiant point against West Ham last time out.
Their last loss was in December of last year to Manchester City. A win here would help them climb out of relegation contention, leap frogging above their opponents to a potential season high of 14th.
Team news - Brentford
Brentford come into the game with, for the first time this season, a fully fit squad, this means the inclusion of star striker who had found himself amongst controversy, Ivan Toney.
There will also be the eagerly anticipated debut of Christian Eriksen, who signed a short term deal with the Bees in January.
It is unsure whether he will make the starting eleven, but his appearance is due after Thomas Frank confirmed in his press conference regarding the game on Saturday.
Team news - Newcastle
Newcastle on the other hand do have injury issues to deal with. The continued absence of Kieran Trippier will be a sore miss.
However there are the potential returns of French starlet, Allan Saint Maximin, who missed out with a calf issue against West Ham, although his presence isn't confirmed as Howe will make a 'late call'.
Javier Manquillo may return to the team, but again may not be up to fitness.
Luckily for The Magpies though is that the squad that travelled to the London Stadium came back unscathed.
When these two sides met earlier in the season it proved to be a Premier League classic in a six-goal thriller.
It ended three all St James' Park in Eddie Howe's first game, even though he could not attend after testing positive for COVID-19.
Ones to watch
Brentford - Christian Eriksen
He will no doubt have retained his superb quality on the ball and of course his dead ball specialties.
Newcastle - Joe Willock
He found his first goal of the season last time out, with a smart finish just before half time to equal the game.
His partnership with Jonjo Shelvey and Joelinton has excelled his performances and cemented his sport in the starting eleven.
Brentford: Raya, Ajer, Jansson, Pinnock, Canos, Dasilva, Norgaard, Janelt, Henry, Mbuemo, Toney (3-5-2)
Newcastle: Dubravka, Manquillo, Schar, Burn, Targett, Willock, Shelvey, Joelinton, Fraser, Saint-Maximin, Wood (4-5-1)
Where to watch
This game falls on Saturday at 3pm, so due to the blackout it will unable to be viewed live.
However, highlights will be posted to YouTube shortly after the final whistle.