Pep Guardiola's men recorded a resounding first-leg advantage thanks to goals from Riyad Mahrez, Bernardo Silva, Phil Foden and Raheem Sterling to put one foot in the door of the Champions League quarter-finals.
Both clubs come off the back wins on the weekend, too. Rúben Amorim's team beat Arouca 2-0 while the Citizens came out on top in the Manchester Derby as 4-1 victors.
While Pep Guardiola would typically rotate giving his team's advantage, injuries and suspensions have limited his options.
Guardiola told Sky Sports: "We have just 14 players available. We have a little bit of problems with suspension for Kyle (Walker) and João (Cancelo) is sick."
Kyle Walker continues to serve his three-match ban from European football while fellow full-back João Cancelo will miss out due to illness. Defenders Rúben Dias and Nathan Aké are also unavailable due to injury meaning four senior figures in the City backline are out of contention.
Pep also warns his team that there is no room for complacency if City are to progress.
The manager added: "We start the game 5-0 but it is not done. Football is unpredictable.
"We will try to do the best team possible to win the game."
For the visitors, trio João Palhinha, Daniel Bragança and wonderkid Pedro Gonçalves will not play in the return leg. A massive blow for the Primeira Liga club.
Manchester City: Ederson; Stones, Fernandinho, Laporte, Zinchenko; Gündoğan, Rodri, Foden; Mahrez, Jesus, Sterling.
Sporting Lisbon: Adán; Inácio, Coates, Reis; Porro, Tabata, Essugo, Vinagre; Sarabia, Santos, Slimani.
Ones to Watch
The England international could return to the eleven after not being involved in the Manchester derby and after his performance in Lisbon, Sterling could cause issues for Sporting.
The no. 7 registered a goal and assist in the Portuguese capital amid a respectable season for the 27-year-old. With 13 goals in all competitions, Sterling has been a vital cog in a cohesive attacking machine as his side gun for both league and continental glory. Can he add to that tally next time out?
The Manchester City loanee has enjoyed a now two-year spell in Portugal, causing all sorts of issues for defenders from his wing-back position.
The 22-year-old has picked up six goal contributions in just 12 league starts this campaign while being part of a team boasting the best defensive record in the Portuguese top-flight - conceding just 16 goals.
With the tie possibly out of reach for the visitors, it may be time for some individual brilliance to revive this contest back to life. And who better than a man looking to impress his parent club.
The 5-0 affair at the Estádio José Alvalade was the latest in just three encounters between these two clubs in their history.
The first meetings date back to 2012 in the UEFA Europa League round of 16. Current Italy manager Roberto Mancini was at the helm for Man City as the English side progressed to the next round via away goals.
Where to watch
This Champions League second-leg clash takes place on Wednesday 9th March at 20:00 GMT.
Fans can watch the match on BT Sport 2 and BT Sport Ultimate with coverage starting at 19:00 GMT.