A loss for either side could mark the end of their participation depending on the outcome of the game between Austria and the Netherlands, so a result here is vital if either team have any hope of advancing to the knockout stages.
Oleksandr Zubov picked up a foot injury in the 13th minute against the Netherlands and may miss this match while Ruslan Malinovskiy and Oleksandr Zinchenko have plenty of experience on the big stage and will have to play crucial roles if Ukraine are to emerge victorious.
Ilija Nesterovski has an ACL injury and has been ruled out of the tournament while the 37-year old Pandev has been excellent for North Macedonia and will look to continue his fine form for the Lions.
Ukraine: Bushchan; Karavaev, Zabarnyi, Matviyenko, Mykolenko; Zinchenko, Sydorchuk, Malinovskyi; Yarmolenko, Yaremchuk, Tsygankov
North Macedonia: Dimitrievski; S. Ristovski, Musliu, D. Velkovski, Alioski; Nikolov, Ademi, Bardi; Elmas, Pandev, Trajkovski
This is the fifth all-time matchup between the sides with Ukraine having won twice, North Macedonia once and one draw. Their last meeting was during the qualifying rounds of Euro 2016 with the Blue and Yellow coming out on top 2-0 courtesy of a 59th-minute penalty from Yevhen Seleznyov and a Artem Kravets goal three minutes from time.
Andriy Yarmolenko had an early Goal of the Tournament contender when he struck against the Dutch, which equalized the match. He's second on the all-time goal-scoring list behind his manager Andriy Shevchenko and will look to continue his good form in this match.
Goran Pandev scored North Macedonia's first-ever goal in a major international game in the loss to Austria. The Genoa striker is the Lions' all-time leading scorer with 39 goals and became the first Macedonian player to net 100 times at club level.
Shevchenko isn't taking North Macedonia lightly, especially after the performance the Lions had in their match against Austria.
"This is a team that deserves respect", he said. "They have character, they have outstanding leaders and a well-established playing system. They almost always play 5-3-2 and they like to countertattack.
"They are good fighters, as well. So we don't expect any gifts from them tomorrow."
The Yellow and Blue boss also explained how his side would approach tomorrow's key clash.
"First of all, we need to play our best game. We have our worked-out playing pattern and much will depend on the midfield - how they will move and how they will move the ball, the speed and precision of their passes.
"We are a team that loves to attack. Being clinical will be the key tomorrow."
North Macedonia manager Igor Angelovski knows the Lions will have to be at their very best to claim all three points.
"We have to play at our very best - this is the EURO", he said. "Only then can we earn a good result. We came to the EURO to reach the Round of 16. Whoever wins this match will improve their chances to advance.
"We are not feeling any pressure, we are motivated, and we will play to win."
Media Sports Ukraine will show the match in Ukraine while MKRTV/Sportklub are the television carriers in North Macedonia. ESPN has coverage in the United States with the match kicking off at 15:00 BST.