A win for either side will take them up a place in the table but, as it is the lunch-time kick-off, it could only be for a short time.
The visitors have only lost three of their last 12 games stretching back to the middle of December, whereas Burnley have picked up just one win since the 3-2 victory over Aston Villa back at the end of January.
Johann Berg Gudmundsson and Jack Cork are doubts, meaning Dale Stephens could be called into the centre of midfield with Ashley Westwood.
Injury-wise for Arsenal, it is a relatively empty list.
Emile Smith-Rowe is likely to miss the game after being withdrawn at the King Power Stadium last weekend, so Martin Odegaard will take his place.
But Mikel Arteta faces a big selection headache after he heavily rotated his side last weekend and witnessed one of his side’s better performances of the season.
With the Europa League returning in midweek, he could be inclined to leave out some of his stars again, but Pierre-Emerick Aubameyang, Bukayo Saka, Hector Bellerin and Rob Holding could all be recalled, with Nicolas Pepe retaining his starting place after an upturn in performances as of late.
Pope; Lowton, Tarkowski, Mee, Taylor; Brownhill, Westwood, Cork, McNeil; Wood, Vydra.
Leno; Bellerin, Holding, Luiz, Tierney; Xhaka, Partey; Saka, Odegaard, Pepe; Aubameyang.
Historically this game, in the Premier League era at least, has been horrifically one sided.
Arsenal have won all but three of their previous 13 league meetings, with an FA Cup win sandwiched in their too.
However, they haven’t beaten Burnley since the beginning of the 2019/20 season, including defeat last time out when Aubameyang scored an own goal.
Speaking of Aubameyang, he has scored more Premier League goals against Burnley than any other team (7).
If Burnley are to win this weekend, it will be the first time since the 1962/1963 season that The Clarets complete the double Arsenal.
They are the second lowest scorers in the league this season, though, only behind basement side Sheffield United, making that a difficult task.
The Gunners have scored 23 goals in the previous 13 games against Burnley, The Clarets have only found the net seven times in that time.
Arsenal 0-1 Burnley (13/12/2020, Premier League)
Pierre-Emerick Aubameyang’s own goal condemned Arsenal to a fourth straight defeat, with the 2000 Arsenal fans in the ground jeering the team off the pitch.
Granit Xhaka was sent off for grabbing Ashley Westwood’s throat 10 minutes after half time, before Aubameyang flicked Westwood’s corner over his own goalkeeper into the net 17 minutes from time.
Nick Pope was the busier of the two ‘keepers but wasn’t challenged too much, making a reflex save from Alexandre Lacazette.
It was a much needed win for The Clarets, who climbed out of the bottom three for the first time all season, while Arsenal were left five points from 18th placed Fulham in 15th.
How to watch
Burnley vs Arsenal is live on BT Sport, kick-off is at 12:30pm GMT.
VAVEL will have live text commentary of the game if you are unable to watch.