The Owls come into the game sat second-bottom and are winless in their last eight games. They are nine points behind 21st-placed Birmingham City with a game in hand.
Barnsley captain Alex Mowatt is available after his red card in the win at Wycombe was overturned. It's a big boost as he has six goals and seven assists to his name this season.
Defenders Ben Williams and Liam Kitching remain sidelined due to their respective injuries.
Sam Hutchinson sustained a muscular injury against Huddersfield but could feature.
Collins; Sibbick, Helik, Andersen; Brittain, Palmer, Mowatt, Styles; Frieser, Woodrow; Dike. (3-4-2-1)
Westwood; Urhoghide, Lees, Borner; Palmer, Pelupessy, Bannan, Reach; Harris, Rhodes, Windass. (3-4-3)
Ones to watch
Daryl Dike - Barnsley
Dike arrived on loan until the end of the season in the January window after an impressive first season with MLS side Orlando City. The United States international scored eight goals and assisted four in 17 games for the Lions, which saw him named Rookie of the Year.
He has five goals in 10 appearances for Barnsley, who could make the deal permanent in the summer.
Josh Windass - Sheffield Wednesday
Windass joined Wednesday from Wigan Athletic on a permanent this season after a loan spell last campaign. He is their joint top scorer with Callum Paterson on six goals and has one assist. The 27-year-old netted an early opener against the Tykes in December, but his side lost 2-1.
The 2-1 win in December for Barnsley was a rarity in this fixture. It is their only victory in the last 13 meetings.
The Owls are also unbeaten at Oakwell since the 08/09 season, which is the last time the Tykes completed the double over them.
The previous four encounters at Oakwell ended 1-1.
Earlier in the season...
How to watch
The match starts at 15:00 GMT and can be watched for £10 with an iFollow pass.
What the managers have said
Valerien Ismael via barnsleyfc.co.uk:
“They have a new manager and I saw their game against Norwich City recently, and in the first half they gave a very good performance. I can see already that the manager is trying to put his own style into the team.
“But we are prepared for the game. As soon as Wycombe was over we switched to this game against Sheffield Wednesday and we know they could play different ways.
“We have shown though, that we can adapt. We have the capability at any moment to change.
“It’s another big fight, and we have to give our supporters another reward on Saturday.”
Darren Moore via swfc.co.uk:
“We are looking forward to the game. They are doing really well but we have to be ready to compete.
“The manager has brought a good tempo and energy to their play. He has led them on a real surge.
“He has given them a wonderful opportunity in terms of getting back to the top-flight of English football. It is credit to them.
“It is a tough game but it is a game that we are prepared for.
“I have got tunnel vision on the games. It’s all about trying to control where we are.
"It will take some time to get that identity right. The immediate focus is on winning the games and making sure we are 100 per cent committed to the matches ahead of us."