Paul Clement will be taking charge of his third game for the club, with Saturday's clash being his first in charge of the Swans at home.
The Gunners impressive on their travels
Up until mid December, where they suffered back-to-back defeats away at Everton and Manchester City, Arsenal had the best away record and defensive record away from home in the league.
Though Arsene Wenger's side bounced back from those two defeats with consecutive home wins, the Gunners then drew 3-3 away at Bournemouth in their last Premier League clash.
Swansea, on the other hand, hold one of the worst home and defensive records in the league. Saturday's hosts have four wins to their name all season, scoring 23 goals and conceding 45 in the process, giving new manager Clement a real task to turn things around in South Wales.
A sign of hope for Swansea?
Swansea can take hope heading in to Saturday's game that their current record against Arsenal is pretty impressive, with the Swans being a real 'bogey side' for the Gunners in previous years.
Their most recent clash at the Emirates Stadium back in October, where Arsenal prevailed 3-2, was in fact the Gunners' first win at home to Swansea since September 2011.
Prior to that defeat, the Welsh side had won on their previous two visits to the Emirates, with the Gunners only winning three times at the Liberty also.
Both sides changed their team selections drastically when featuring in last weekend's third round of the FA Cup. Though many big names will return for both teams.
Arsenal will expect both Mesut Ozil and Alexis Sanchez to return to the side when they travel to Wales this weekend.
Ozil missed the Gunners' last three games following illness, while Sanchez was rested as Arsenal won 2-1 at Preston in the FA Cup.
Laurent Koscielny will also return to captain the side after he was rested last weekend.
Though Arsenal will still be without Theo Walcott and Hector Bellerin for their trip to the Liberty.
As for the home side, they will be without full-back Neil Taylor who is missing after fracturing his cheekbone in training.
Unfortunately for the Swans new signing Luciano Narsingh, who joined from PSV Eindhoven, is not available for selection due to a calf injury.
Swansea City: Fabianski; Naughton, Fernandez, Mawson, Rangel; Fer, Ki Sung-yueng, Cork; Routledge, Sigurdsson, Llorente.
Arsenal: Cech; Gabriel, Koscielny, Mustafi, Monreal; Xhaka, Ramsey; Ozil, Sanchez, Iwobi, Giroud.