The two teams are separated by only three points but the Dons have two games in hand over their relegation rivals. A win for either side will push themselves out of the relegation zone, if other results go their way.
Jayden Stockley opened the scoring for the visitors in the 10th minute but it was cancelled out by a Ryan Longman equaliser.
Fifth minute substitute, Diallang Jaiyesimi, put Athletic back in front just before the halfway stage of the first half by smashing the ball past Nikola Tzanev.
Into the second half, Longman got his second of the game. The midfielder pounced on a poor mistake from the Charlton defence and brought the game back to all square.
On Tuesday, Northampton Town secured three very vital points in their bid for safety as the Cobblers climbed outside the relegation zone.
The only major chance of the first half fell to Mark Marshall. The Northampton winger scuffed his shot against the post, stopping the hosts going 1-0 up.
In the 55th minute, Peter Kioso found Danny Rose who played a brilliant pin-point pass through to Sam Hoskins who perfectly finished the team goal into the bottom corner.
Callum Reilly and Zach Robinson are likely to miss out with both players nursing hamstring injuries.
Shayon Harrison will also be unable to play due to an ankle injury sustained last weekend.
Following a small injury, Ethan Chislett is now in contention for the match.
Mickel Miller could return to the match day squad after a slight hamstring injury.
However, Jack Sowerby and Steve Arnold are both set to miss Saturday's game.
Walker; Johnson, Heneghan, Nightingale, Guinness-Walker; Woodyard, Dobson; Rudoni, Chislett, Longman; Pigott.
Mitchell; Kioso, Jones, Horsfall, Mills; Morris, McWilliams, Watson; Marshall, Rose, Hoskins.
Ones to watch
AFC Wimbledon - Joe Pigott
Joe Pigott is undoubtedly the one to watch for Wimbledon. The striker has been in fine form this season, with 13 goals in the league and five assists.
Despite not scoring since his brace against Wigan at the start of the month, Pigott will look in be in and around the goals this weekend as he takes on a team up the other end of the table.
Northampton Town - Sam Hoskins
Hoskins is one of Town's key players this season, having the most goal contributions in the team. Scoring four goals and getting six assists so far this season, the right winger will be looking to add to his current tally.
Northampton Town 2-2 AFC Wimbledon (12/09/2020)
Where to watch
UK residents will be able to watch the game available on iFollow with kick off at 15:00 GMT on Saturday March 27.