The U's are on a magnificent seven-game winning streak, but on Saturday they welcome Fleetwood Town, a side they have not beaten in 12 previous attempts.
Having suffered five defeats in all five encounters with The Fishermen at home, Karl Robinson will hope his side's 2021 fortuity can continue upon the 15:00 blackout this weekend.
The home side head into the fixture fresh off the back of a breathtaking spectacle at Rochdale's Spotland Stadium, where they came out 4-3 victors.
Meanwhile, Fleetwood are struggling to find the net; the visitors have neither scored nor conceded in their last two League One matches against Wigan Athletic and Northampton Town.
Oxford United continue their relentless run of fixtures; they play midweek for another two weeks, which would suggest that rotation is in the offing for Robinson.
Cameron Brannagan featured in midweek against Rochdale, deputising for the injured Marcus McGuane, who will be out for around a month yet. Brannagan is likely to stay in the lineup before being rested in Tuesday night's Papa John's Trophy quarter-final.
It's all positive news in the Oxford camp other than the injury to McGuane though, as the U's have depth in choice heading into the fixture.
There are no known new injuries that have cropped up for Simon Wiles, giving the Fleetwood boss a selection headache on Saturday.
Ones to watch
Oxford United: Matty Taylor
Oxford's top goalscorer, Matty Taylor, has been at his very best in recent weeks. The striker, who failed to net at Spotland in midweek, has scored three goals in his previous two starts for the Yellows before that.
His linkup play with loanee Olamide Shodipo will be the focus of the game on Saturday, as Oxford look to find a way through Fleetwood's strong defence.
The Yellows have found a way through opposition defences with ease as of late, but the Fishermen pose a stronger defensive block. Taylor will be indispensable in Oxford's efforts to find a breakthrough.
Fleetwood Town: Danny Andrew
Danny Andrew has started all but one of Fleetwood's League One fixtures this campaign, playing a key role in their defensively impressive record, the seventh-best in the league.
The fullback will undergo a stern test when he is dealt the task of keeping James Henry and Matty Taylor quiet on the right-hand side of Oxford's attack.
A high-level performance from Andrew could pose a problem for Oxford going forward. Can the Fishermen keep their third consecutive clean sheet?
Oxford United (4-3-3):
Stevens; Ruffels, Atkinson, Moore, Long; Kelly, Rodriguez, Brannagan; Shodipo, Taylor, Henry.
Fleetwood Town (4-2-3-1):
Cairns; Andrew, Mulgrew, Connolly, Donacien; Rossiter, Finley; Saunders, Camps, Duffy; Madden.
Last time out
It has been two years since these two last met at Grenoble Road after the coronavirus pandemic ruled out Fleetwood's visit at the backend of last season.
Joey Barton celebrated his first win as the Fleetwood boss on that day in August 2018. Goals from Ched Evans and Paddy Madden secured three points for the Fishermen.
How to watch
The match is available on iFollow through Oxford United and Fleetwood Town's respective club websites, with match passes at £10 for those in the United Kingdom.