The Europa League is starting to look like the only path for European football next season, with Mikel Arteta's side desperately hoping to return to good form.
Whereas for Slavia Prague, they have continued their dominance at the top of the Czech First League and look to rock the Arsenal boat even further.
However, controversies surrounding the Czech side may encourage an Arsenal victory in North London, as the world of football continues their battle against racism and discrimination.
When it seemed Arsenal's injury crisis had been averted, players are beginning to pile up again.
As previously stated by the club, David Luiz will miss out once again due to undergoing successful knee surgery.
Slavia Prague are also facing similar issues. Ondřej Kúdela, who is facing racism allegations following an incident with Rangers' Glen Kamara, has reportedly fallen ill approaching Thursday night.
Although this is the case, the Czech international would not have been able to play due to his UEFA one-match ban as the investigation continues.
The First League champions will also be without centre-backs Simon Deli and David Hovorka, which will prove a test as they travel to North London.
Ones to watch
However, his comfort on the ball, and his eye for a killer pass could provide crucial chances in this tie. A strikers dream against a weakened Slavia Prague defence.
Nicolae Stanciu - The Romanian midfielder is having a season to remember. Stanciu has scored 13 goals this season, including three in the Europa League, scoring in critical moments.
He has eight in his last six matches for the Czech side, which may been a worry for a shaky and injury poisoned Arsenal.
Predicted line ups
Arsenal - Ryan; Bellerin, Holding, Mari, Cedric; Partey, Elneny; Saka, Odegaard, Pepe; Lacazette.
Slavia Prague - Vagner; Bah, Zima, Hromada, Boril; Holes, Sevcik; Sima, Stanciu, Olayinka; Kuchta
How to watch
Arsenal v Slavia Prague will kick off at 8pm BST and will be broadcasted live on BT Sport.