Ole Gunnar Solskjaer's side have already clinched a top four spot, giving the Man United boss some room to experiment with his squad. Meanwhile, Leicester remain in the hunt for a Champions League place and will be out to seal three points.
Here is a look at how the two sides could take shape.
Solskjaer has already admitted he will have to rotate the squad during the gruelling fixture schedule United find themselves in. Wholesale changes could be made for this fixture as a result and a number of experienced players as well as youngsters could be in line for some game time.
Harry Maguire looks likely to be missing against his former club having suffered an ankle injury against Villa. Eric Bailly or Axel Tuanzebe could take the skipper's place at the heart of the defence. Daniel James is also a doubt and looks set to join long-term absentee, Anthony Martial, on the sidelines.
The news is more positive for youngsters Amad and Shola Shoretire who are in contention for some first-team minutes whilst Anthony Elanga, Hannibal and Will Fish could also find themselves in the squad.
Over in the opposition camp, former Red Johnny Evans looks set to sit this one out having picked up an injury during the warm-up prior to the Foxes 4-2 defeat to Newcastle United at the weekend.
Harvey Barnes and James Justin are out for the season and will definitely not feature here and although Leicester have an FA Cup final against Chelsea approaching, they cannot afford to field a weakened team against United with their top four position still in the balance.
However, key players James Maddison and Ricardo Pereira have recently returned from injury and Brendan Rodgers may not want to risk them.
Henderson, Williams, Lindelof, Bailly, Telles, Matic, Van de Beek, Mata, Fernandes, Greenwood, Cavani.
Schmeichel, Castagne, Soyuncu, Fofana, Pereira, Tielemans, Ndidi, Albrighton, Perez, Iheanacho, Vardy.