The Yellow Army have adapted brilliantly to life in EFL League Two, sitting in eighth place on 26 points while the O's are just one place and two points behind their guests.
Callum Reilly has been ruled out for Leyton Orient through injury while Tyrese Omotoye will face a late fitness test to determine his status.
Tobi Sho-Silva and Enzio Boldewijn are out for Sutton while Omar Bugiel returns following international duty with Lebanon.
Leyton Orient: Vigouroux; Clay, Beckles, Ogie; James, Pratley, Kyprianou, Archibald; Drinan, Smith, Kemp
Sutton United: Bouzanis; Wyatt, Rowe, Goodliffe, Kizzi; Randall, Smith, Eastmond, Ajiboye; Olaofe, Bennett
Ones to watch
Aaron Drinan (Leyton Orient)
The Irishman faces the team that he spent a season on loan with, scoring a memorable goal in the FA Cup. He's the O's top offensive threat, scoring seven goals in 12 appearances this season.
David Ajiboye (Sutton United)
The 23-year-old winger has been one of Sutton's best players in their debut season in the Football League, registering three goals and two assists while playing in all 15 league games so far.
Leyton Orient have won their last three matches against Sutton United, the last of which was a 2-1 victory in 2019 on a 90th-minute goal by Macaulay Bonne from the penalty spot with the O's down to ten men.
The man in charge will be Scott Oldham with Nicholas Cooper and Paul Yates as his assistants. Andy Bennett is the fourth official.
How to watch
There will be no live television coverage of this match, but the Sutton iFollow channel, iFollow U's, will provide audio commentary.
Leyton Orient will also provide audio commentary with kick-off set for 15:00 BST. Those outside of the UK & Ireland can watch a live stream of the match via both club websites.